Inventors:
Curt Horvath - Wilmette IL, US
Jason Rodriguez - Evanston IL, US
Christina Ulane - New York NY, US
Jean-Patrick Parisien - Wilmette IL, US
International Classification:
A61K 48/00, C12N 15/867
Abstract:
The invention relates to compositions and methods for modulating cell signaling mediated by signal transducers and activators of transcription (STAT). The compositions target cellular STAT3 and STAT1 protein, particularly STAT3, for degradation via the ubiquitination pathway. Thus, the STAT inhibiting agents are useful for inhibiting STAT mediated signal transduction events, such as responses to IL6 and v-Src, any may be applied to treating diseases associated with activated STAT proteins, particularly STAT3 activity, such as cell proliferative disorders, inflammatory reactions, and autoimmune conditions.