Inventors:
Nalli Ma - Wirchester MA, US
Terry Strom - Brookline MA, US
Miguel Soares - Boston MA, US
Christiane Ferran - Brookline MA, US
Manikkam Suthanthiran - Scarsdale NY, US
International Classification:
C12Q001/68
Abstract:
The invention relates to methods of evaluating transplant rejection in a host comprising determining a heightened magnitude of gene expression of genes in rejection-associated gene clusters. The disclosed gene clusters include genes that are substantially co-expressed with cytotoxic lymphocyte pro-apoptotic genes, cytoprotective genes and several other cytokine and immune cell genes.