CHRISTIAN W SCHINDLER, MD
Osteopathic Medicine at Fort Washington Ave, New York, NY

6605442, Aug 12, 2003

Mar 11, 1994

08/212185

Christian W. Schindler - New York NY
Xin-Yuan Fu - Forrest Hills NY
Zilong Wen - New York NY
Zhong Zhong - New York NY

The Rockefeller University - New York NY

G01N 3353

435 721, 435 71, 435 72

Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN and IFN. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission.

6338949, Jan 15, 2002

Oct 23, 1997

08/956653

Christian W. Schindler - New York NY
Xin-Yuan Fu - Forrest Hills NY
Zilong Wen - New York NY
Zhong Zhong - New York NY

The Rockefeller University - New York NY

C07H 2104

435 691, 435325, 4352523, 4353201, 530350, 536 235

Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN and IFN. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission.

7339039, Mar 4, 2008

Jun 7, 2001

09/876773

Christian W. Schindler - New York NY, US
Xin-Yuan Fu - Forrest Hills NY, US
Zilong Wen - New York NY, US
Zhong Zhong - New York NY, US

The Rockfeller University - New York NY

C07H 21/04, C12P 21/06, C07K 14/00

536 231, 435 691, 530350

Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted With interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFNα and IFNγ. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission.

7060682, Jun 13, 2006

Aug 12, 2003

10/639617

Christian W. Schindler - New York NY, US
Xin-Yuan Fu - Forrest Hills NY, US
Zilong Wen - New York NY, US
Zhong Zhong - New York NY, US

The Rockefeller University - New York NY

A61K 38/17, C07K 14/46

514 12, 530350

Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFNα and IFNγ. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission.

5976835, Nov 2, 1999

Mar 19, 1997

8/820754

James E. Darnell - Larchmont NY
Christian W. Schindler - New York NY
Xin-Yuan Fu - Forrest Hills NY
Zilong Wen - New York NY
Zhong Zhong - New York NY

The Rockefeller University - New York NY

C07H 2100, C12N 1512

435 691

Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN. alpha. and IFN-. gamma. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission.

6030808, Feb 29, 2000

Oct 23, 1997

8/956869

James E. Darnell - Larchmont NY
Christian W. Schindler - New York NY
Xin-Yuan Fu - Forrest Hills NY
Zilong Wen - New York NY
Zhong Zhong - New York NY

The Rockefeller University - New York NY

C07H 2104, C12N 1512, C12N 1563

435 691

Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN. alpha. and IFN-. gamma. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission.

6013475, Jan 11, 2000

Oct 23, 1997

8/956652

James E. Darnell - Larchmont NY
Christian W. Schindler - New York NY
Xin-Yuan Fu - Forest Hills NY
Zilong Wen - New York NY
Zhong Zhong - New York NY

The Rockfeller University - New York NY

C12N 1512

435 691

Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN. alpha. and IFN. gamma. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission.

6124118, Sep 26, 2000

Oct 10, 1997

8/948547

James E. Darnell - Larchmont NY
Christian W. Schindler - New York NY
Xin-Yuan Fu - Forrest Hills NY
Zilong Wen - New York NY
Zhong Zhong - New York NY

The Rockfeller University - New York NY

C12P 2106, C07H 2104

435 691

Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN. alpha. and IFN. gamma. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission.