DR. CHRISTIAN HUNTER, M.D., PH.D.
Osteopathic Medicine at Francis St, Boston, MA

2010024, Sep 30, 2010

Mar 26, 2010

12/748184

Mark T. Gladwin - Pittsburgh PA, US
Alan N. Schechter - Bethesda MD, US
David J. Lefer - Atlanta GA, US
Rakesh P. Patel - Hoover AL, US
Christian J. Hunter - Boston MA, US
Gordon G. Power - Redlands CA, US
Daniel B. Kim-Shapiro - Winston-Salem NC, US
Ryszard Marek Pluta - Bethesda MD, US
Edward H. Oldfield - Philomont VA, US

A61K 33/00, A61K 31/198, A61P 9/00, A61P 11/00

424718, 514565

It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

2012019, Aug 2, 2012

Feb 28, 2012

13/407118

Mark T. Gladwin - Washington DC, US
Alan N. Schechter - Bethesda MD, US
Christian J. Hunter - Boston MA, US
Gordon G. Power - Redlands CA, US
Daniel B. Kim-Shapiro - Winston-Salem NC, US

A61K 33/00, A61P 9/10, A61P 9/12

424718

It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.