Inventors:
Larry F. Lemanski - Boynton Beach FL, US
Chi Zhang - Pompano Beach FL, US
Assignee:
Florid Atlantic University - Boca Raton FL
International Classification:
C07H 21/02, C07H 21/04, C12Q 1/68, C12N 15/00
US Classification:
536 231, 435 6, 435 691, 4353201
Abstract:
Compositions and methods for inducing a cardiac muscle phenotype, such as rhythmic contraction and formation of myofibrils, in a cell are described. Disclosed are nucleic acids encoding myofibrillogenesis-inducing RNA (MIR) molecules, RNA molecules (MIR) and RNA-binding proteins that bind to MIR to induce myofibrillogenesis and vectors comprising these nucleic acids. Also included is a method of promoting cardiac muscle differentiation using these compositions.