Inventors:
Gregory Joseph Riggins - White Hall MD, US
Meghan Joyce Seltzer - Herndon VA, US
Takashi Tsukamoto - Ellicott City MD, US
Chi Van Dang - Penn Valley PA, US
Ashkan Emadi - Bethesda MD, US
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
A61K 31/433, A61K 31/704
US Classification:
514 34, 514363, 435375, 435 18
Abstract:
Methods for treating a cancer having a mutant isocitrate dehydrogenase (IDH), including, but not limited to, a malignant low-grade glioma, a secondary glioblastoma, a transforming myeloproliferative disorder (tMPD), and an acute myelogenous leukemia (AML), with a glutaminase inhibitor, including, bis--(-phenylacetamido--thiadiazol--yl)ethyl sulfide (BPTES), are disclosed.