CHARLOTTE COFFEN
Nursing in Riverside, MD
License number
New Jersey 26NR05396100
Issued Date
Jan 12, 1981
Expiration Date
May 31, 2009
Category
Nursing
Type
Registered Prof. Nurse
Address
Address
Riverside, MD
Professional information
Compounds, Compositions And Methods For The Treatment Of Amyloid Diseases And Synucleinopathies Such As Alzheimer's Disease, Type 2 Diabetes, And Parkinson's Disease
US Patent:
2009019, Aug 6, 2009
Filed:
Nov 11, 2008
Appl. No.:
12/269017
Inventors:
Alan D. Snow - Lynnwood WA, US
Beth P. Nguyen - Bothell WA, US
Gerardo M. Castillo - Bothell WA, US
Virginia J. Sanders - Seattle WA, US
Thomas P. Lake - Snohomish WA, US
Lesley Larsen - Sawyers Bay, NZ
Rex T. Weavers - Maryhill, NZ
David S. Lorimer - Opoho, NZ
David S. Larsen - Sawyers Bay, NZ
David L. Coffen - San Diego CA, US
Charlotte Coffen - Belcamp MD, US
Stephen D. Lorimer - Opoho, NZ
Beth P. Nguyen - Bothell WA, US
Gerardo M. Castillo - Bothell WA, US
Virginia J. Sanders - Seattle WA, US
Thomas P. Lake - Snohomish WA, US
Lesley Larsen - Sawyers Bay, NZ
Rex T. Weavers - Maryhill, NZ
David S. Lorimer - Opoho, NZ
David S. Larsen - Sawyers Bay, NZ
David L. Coffen - San Diego CA, US
Charlotte Coffen - Belcamp MD, US
Stephen D. Lorimer - Opoho, NZ
International Classification:
A61K 31/17, C07C 233/56, A61K 31/167, C07C 275/34, A61P 25/28
US Classification:
514598, 564158, 514616, 564 52
Abstract:
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
Compounds, Compositions And Methods For The Treatment Of Amyloid Diseases And Synucleinopathies Such As Alzheimer's Disease, Type 2 Diabetes And Parkinson's Disease
US Patent:
2011017, Jul 14, 2011
Filed:
Jul 16, 2010
Appl. No.:
12/837721
Inventors:
Alan D. SNOW - Lynnwood WA, US
Beth NGUYEN - Trophy Club TX, US
Gerardo CASTILLO - Bothell WA, US
Virginia SANDERS - San Francisco CA, US
Thomas LAKE - Snohomish WA, US
Lesley LARSEN - Dunedin, NZ
Rex T. WEAVERS - Dunedin, NZ
Stephen LORIMER - Dunedin, NZ
David LARSEN - Dunedin, NZ
David L. COFFEN - San Diego CA, US
Charlotte COFFEN - Belcamp MD, US
Beth NGUYEN - Trophy Club TX, US
Gerardo CASTILLO - Bothell WA, US
Virginia SANDERS - San Francisco CA, US
Thomas LAKE - Snohomish WA, US
Lesley LARSEN - Dunedin, NZ
Rex T. WEAVERS - Dunedin, NZ
Stephen LORIMER - Dunedin, NZ
David LARSEN - Dunedin, NZ
David L. COFFEN - San Diego CA, US
Charlotte COFFEN - Belcamp MD, US
International Classification:
A61K 31/495, C07C 49/83, A61K 31/12, A61P 25/28, A61P 25/00, A61P 25/16, C07C 39/16, A61K 31/05, A61K 31/4418, C07D 213/85, C07D 295/096, C07C 215/50, A61K 31/137, C07D 451/06, A61K 31/46, C07C 235/50, A61K 31/166
US Classification:
51425212, 568331, 514685, 568723, 514734, 514344, 546286, 544398, 564306, 514655, 546131, 514304, 564158, 514616, 564179, 514622
Abstract:
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
Compounds, Compositions And Methods For The Treatment Of Amyloid Diseases And Synucleinopathies Such As Alzheimer's Disease, Type 2 Diabetes And Parkinson's Disease
US Patent:
2012022, Sep 6, 2012
Filed:
Mar 6, 2012
Appl. No.:
13/413417
Inventors:
Alan D. Snow - Lynnwood WA, US
Beth Nguyen - Trophy Club TX, US
Gerardo Castillo - Bothell WA, US
Virginia Sanders - San Francisco CA, US
Thomas Lake - Snohomish WA, US
Lesley Larsen - Dunedin, NZ
Rex T. Weavers - Dunedin, NZ
Stephen Lorimer - Dunedin, NZ
David Larsen - Dunedin, NZ
David L. Coffen - Dunedin, NZ
Charlotte Coffen - Belcamp MD, US
Beth Nguyen - Trophy Club TX, US
Gerardo Castillo - Bothell WA, US
Virginia Sanders - San Francisco CA, US
Thomas Lake - Snohomish WA, US
Lesley Larsen - Dunedin, NZ
Rex T. Weavers - Dunedin, NZ
Stephen Lorimer - Dunedin, NZ
David Larsen - Dunedin, NZ
David L. Coffen - Dunedin, NZ
Charlotte Coffen - Belcamp MD, US
International Classification:
A61K 31/495, C07D 211/44, A61K 31/45, C07D 295/10, C07D 241/04, A61P 25/16, A61K 31/44, C07D 213/69, A61P 25/28, A61P 3/10, A61P 29/00, A61P 35/00, C07D 295/096, C07D 213/30
US Classification:
51425501, 544398, 51425212, 546216, 514327, 544383, 544385, 546343, 514277, 546296, 514348
Abstract:
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
Compounds, Compositions And Methods For The Treatment Of Amyloid Diseases And Synucleinopathies Such As Alzheimer's Disease, Type 2 Diabetes, And Parkinson's Disease
US Patent:
2004012, Jul 1, 2004
Filed:
May 30, 2003
Appl. No.:
10/452851
Inventors:
Alan Snow - Lynnwood WA, US
Beth Nguyen - Bothell WA, US
Gerardo Castillo - Seattle WA, US
Virginia Sanders - Seattle WA, US
Thomas Lake - Snohomish WA, US
Lesley Larsen - Dunedin, NZ
Rex Weavers - Dunedin, NZ
Stephen Lorimer - Dunedin, NZ
David Larsen - Dunedin, NZ
David Coffen - San Diego CA, US
Charlotte Coffen - Belcamp MD, US
Beth Nguyen - Bothell WA, US
Gerardo Castillo - Seattle WA, US
Virginia Sanders - Seattle WA, US
Thomas Lake - Snohomish WA, US
Lesley Larsen - Dunedin, NZ
Rex Weavers - Dunedin, NZ
Stephen Lorimer - Dunedin, NZ
David Larsen - Dunedin, NZ
David Coffen - San Diego CA, US
Charlotte Coffen - Belcamp MD, US
International Classification:
A61K031/34, A61K031/137, C07C049/786, A61K031/075, A61K031/12, A61K031/095
US Classification:
514/464000, 514/646000, 514/649000, 514/706000, 514/721000, 514/734000, 514/689000, 549/435000, 564/336000, 568/047000, 568/337000
Abstract:
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
Compounds, Compositions And Methods For The Treatment Of Amyloid Diseases Such As Systemic Aa Amyloidosis
US Patent:
2007022, Sep 27, 2007
Filed:
Mar 5, 2007
Appl. No.:
11/714894
Inventors:
Alan Snow - Lynnwood WA, US
Beth Nguyen - Gurnee IL, US
Gerardo Castillo - Bothell WA, US
Virginia Sanders - San Francisco CA, US
Thomas Lake - Snohomish WA, US
Lesley Larsen - Port Chalmers, NZ
Rex Weavers - Dunedin, NZ
Stephen Lorimer - Dunedin, NZ
David Larsen - Port Chalmers, NZ
David Coffen - Belcamp MD, US
Charlotte Coffen - Belcamp MD, US
Beth Nguyen - Gurnee IL, US
Gerardo Castillo - Bothell WA, US
Virginia Sanders - San Francisco CA, US
Thomas Lake - Snohomish WA, US
Lesley Larsen - Port Chalmers, NZ
Rex Weavers - Dunedin, NZ
Stephen Lorimer - Dunedin, NZ
David Larsen - Port Chalmers, NZ
David Coffen - Belcamp MD, US
Charlotte Coffen - Belcamp MD, US
International Classification:
A61K 31/165, A61K 31/135, A61K 31/167, A61K 31/357
US Classification:
514464000, 514616000, 514622000, 514655000
Abstract:
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
Substituted N-Aryl Benzamides And Related Compounds For Treatment Of Amyloid Diseases And Synucleinopathies
US Patent:
2011010, May 5, 2011
Filed:
Nov 5, 2010
Appl. No.:
12/940330
Inventors:
Alan Snow - Lynnwood WA, US
Manfred Weigele - Cambridge MA, US
Lesley Larsen - Dunedin, NZ
Beth Nguyen - Gurnee IL, US
Thomas Lake - Snohomish WA, US
Gerardo Castillo - Bothell WA, US
Virginia Sanders - San Francisco CA, US
Rex T. Weavers - Dunedin, NZ
Stephen Lorimer - Dunedin, NZ
David Larsen - Dunedin, NZ
David L. Coffen - , US
Charlotte Coffen - Belcamp MD, US
Manfred Weigele - Cambridge MA, US
Lesley Larsen - Dunedin, NZ
Beth Nguyen - Gurnee IL, US
Thomas Lake - Snohomish WA, US
Gerardo Castillo - Bothell WA, US
Virginia Sanders - San Francisco CA, US
Rex T. Weavers - Dunedin, NZ
Stephen Lorimer - Dunedin, NZ
David Larsen - Dunedin, NZ
David L. Coffen - , US
Charlotte Coffen - Belcamp MD, US
International Classification:
A61K 31/167, C07C 233/75, A61K 51/00, A61P 43/00
US Classification:
424 165, 564179, 514622
Abstract:
Compounds and their pharmaceutically acceptable salts, their synthesis and labeling, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided. Also provided is the use of the disclosed compounds as imaging agents and methods for in vivo imaging and detection of amyloid and synuclein.