Inventors:
Henry Freiser - Tucson AZ
Charles R. Martin - Austin TX
Assignee:
University Patents, Inc. - Norwalk CT
International Classification:
G01N 2746
Abstract:
Concentrations of large organic cationic species in aqueous solution are measured as a function of potentiometric response, employing a cation-selective electrode having a high degree of selectivity for large organic cationic species with respect to both smaller organic cationic species and inorganic cationic species. The electrode is formed with a cation-selective membrane component composed of a polymeric matrix having dispersed or dissolved therein a cation exchange material whose counter-anion is a high molecular weight alkyl or alkaryl sulfonate or sulphate. By proper choice of the cationic moiety of the cation exchange material, the electrode may be made selective for a variety of large organic cationic species, including a number of such species which are of pharmaceutical or clinical interest, thereby enabling potentiometric assays for such species.