DR. CHARLES THOMAS CASKEY, MD
Medical Practice at Baylor Plz, Houston, TX

6555654, Apr 29, 2003

Feb 14, 2000

09/402923

John A. Todd - Cambridge, GB
John W. Hess - Lansdale PA
Charles T. Caskey - Houston TX
Roger D Cox - Oxon, GB
David Gerhold - Lansdale PA
Holly Hammond - Telford PA
Patricia Hey - Lansdale PA
Yoshihiko Kawaguchi - Osaka, JP
Tony R. Merriman - Dunedin, NZ
Michael L. Metzker - Ft. Washington PA
Yusuke Nakagawa - Ikeda, JP
Michael S. Phillips - Lansdale PA
Rebecca C. J. Twells - Oxon, GB

The Wellcome Trust Limited as Trustee for the Wellcome Trust - London

C07K 1400

530350, 530300, 435 71, 4353201

A novel receptor, “LDL-receptor related protein-3” (“LRP-3”), is provided, along with encoding nucleic acid. The gene is associated with type 1 diabetes (insulin dependent diabetes mellitus), and experimental evidence provides indication that it is the IDDM susceptibility gene IDDM4. In various aspects the invention provides nucleic acid, including coding sequences, oligonucleotide primers and probes, polypeptides, pharmaceutical compositions, methods of diagnosis or prognosis, and other methods relating to and based on the gene, including methods of treatment of diseases in which the gene may be implicated, including autoimmune diseases, such as glomerulonephritis, diseases and disorders involving disruption of endocytosis and/or antigen presentation, diseases and disorders involving cytokine clearance and/or inflammation, viral infection, elevation of free fatty acids or hypercholesterolemia, osteoporosis, Alzheimers disease, and diabetes.

6545137, Apr 8, 2003

Apr 15, 1998

09/060299

John A. Todd - Tackley, Oxon OX5 3AJ, GB
John W. Hess - Lansdale PA 19446
Charles T. Caskey - Houston TX 66005
Roger D Cox - Oxon OX16 0DW, GB
David Gerhold - Lansdale PA 19446
Holly Hammond - Telford PA 18969
Patricia Hey - Lansdale PA 19446
Yoshihiko Kawaguchi - Suita Shi, Osaka 565, JP
Tony R. Merriman - Oxford OX3 0RX, GB
Michael L. Metzker - Lansdale PA 19446
Yusuke Nakagawa - Oxford OX3 7PQ, GB
Michael S. Phillips - Lansdale PA 19446
Rebecca C.J. Twells - Thame, Oxon OX9 3HU, GB

C07H 2104

536 231, 536 243, 536 234, 536 235, 435 6, 435 691

A novel receptor, “LDL-receptor related protein-3” (“LRP-3”), is provided, along with encoding nucleic acid. The gene is associated with type 1 diabetes (insulin dependent diabetes mellitus), and experimental evidence provides indication that it is the IDDM susceptibility gene IDDM4. In various aspects the invention provides nucleic acid, including coding sequences, oligonucleotide primers and probes, polypeptides, pharmaceutical compositions, methods of diagnosis or prognosis, and other methods relating to and based on the gene, including methods of treatment of diseases in which the gene may be implicated, including autoimmune diseases, such as glomerulonephritis, diseases and disorders involving disruption of endocytosis and/or antigen presentation, diseases and disorders involving cytokine clearance and/or inflammation, viral infection, elevation of free fatty acids or hypercholesterolemia, osteoporosis, Alzheimers disease, and diabetes.

7244577, Jul 17, 2007

Dec 31, 2002

10/331907

John A. Todd - Cambridge, GB
John W. Hess - Lansdale PA, US
Charles T. Caskey - Houston TX, US
Roger D Cox - Oxon, GB
David Gerhold - Lansdale PA, US
Holly Hammond - Telford PA, US
Patricia Hey - Lansdale PA, US
Yoshihiko Kawaguchi - Osaka, JP
Tony R. Merriman - Dunedin, NZ
Michael L. Metzker - Ft. Washington PA, US
Yusuke Nakagawa - Osaka, JP
Michael S. Phillips - Lansdale PA, US
Rebecca C. J. Twells - Cambridge, GB

Merck & Co., Inc. - Rahway NJ

G01N 33/567

435 721

A novel receptor, “LDL-receptor-related protein-5” (“LRP-5”), is provided, along with encoding nucleic acid. The gene is associated with type 1 diabetes (insulin dependent diabetes mellitus), and experimental evidence provides indication that it is the IDDM susceptibility gene IDDM4. In various aspects the invention provides nucleic acid, including coding sequences, oligonucleotide primers and probes, polypeptides, pharmaceutical compositions, methods of diagnosis or prognosis, and other methods relating to and based on the gene, including methods of treatment of diseases in which the gene may be implicated, including autoimmune diseases, such as glomerulonephritis, diseases and disorders involving disruption of endocytosis and/or antigen presentation, diseases and disorders involving cytokine clearance and/or inflammation, viral infection, elevation of free fatty acids or hypercholesterolemia, osteoporosis, Alzheimer's disease, and diabetes.

5364759, Nov 15, 1994

Jan 31, 1991

7/647655

Charles T. Caskey - Houston TX
Albert O. Edwards - Houston TX

Baylor College of Medicine - Houston TX

C12Q 168, C07H 1512, G01N 3348, G01N 33566

435 6

The present invention relates to a DNA profiling assay for detecting polymorphisms in a short tandem repeat. The method includes the steps of extracting DNA from a sample to be tested, amplifying the extracted DNA and identifying the amplified extension products for each different sequence. Each different sequence is differentially labeled. In the method, internal and external standards can also be used. The method is applicable to a wide variety of forensic and medical samples, including blood, semen, vaginal swaps, tissue, hair, saliva, urine and mixtures of body fluids. A short tandem repeat sequence which can be characterized by the formula (A. sub. w G. sub. x T. sub. y C. sub. z). sub. n, wherein A, G, T and C represent the nucleotides, w, x, y and z represent the number of nucleotide and range from 0 to 7 and the sum of w+x+y+z ranges from 3 to 7 and n represents the repeat number and ranges from 5 to 50. The labels can be from a variety of groups, including fluorescers, radioisotopes, chemiluminescers, stains, enzymes and antibodies.

5578458, Nov 26, 1996

Oct 1, 1991

7/769743

Charles T. Caskey - Houston TX
Richard A. L. Gibbs - Houston TX

Baylor College of Medicine - Houston TX

C12Q 168, C12P 1934, C07H 2104

435 6

The present invention relates to a process for the rapid and simple detection of mutations in DNA and differences between DNA sequences. This competitive oligonucleotide priming system can be used for the detection of any differences between DNA sequences for which a DNA sequence is known.

5981185, Nov 9, 1999

May 28, 1997

8/863639

Robert S. Matson - Orange CA
Peter J. Coassin - San Juan Capistrano CA
Jang B. Rampal - Yorba Linda CA
Charles Thomas Caskey - Houston TX

Beckman Coulter, Inc. - Fullerton CA

C12Q 168, C07H 2102, C07H 2100

435 6

A solid support based hybridization assay is provided which allows for the systematic and reproducible analysis of repeat and tandem repeat oligonucleotide sequences of DNA and RNA by hybridization to a reverse dot blot array comprising strings of such repeats complementary to those found in particular nucleic acid targets (e. g. , analyte PCR product). An addressable library (i. e. , an indexed set) of complementary repeats is synthesized on a suitable support. Preferably, the support comprises a low fluorescent background support, thereby facilitating the use of non-radioisotopic modes of detection (such as fluorescence or chemiluminescence); particularly suitable in this regard is an aminated polypropylene support or similar material. Preferred arrays permit screening of DNA and RNA samples for complete sets of particular types of nucleotide repeat sequences (e. g. , all nucleotide doublet or triplet repeats).

5582989, Dec 10, 1996

Sep 30, 1994

8/315673

Charles T. Caskey - Houston TX
Jeffrey S. Chamberlain - Houston TX
Richard A. L. Gibbs - Houston TX
Joel E. Ranier - Houston TX
Phi N. Nguyen - Houston TX

Baylor College of Medicine - Houston TX

C12Q 168, C12P 1934

435 6

The present invention relates to a method for detecting multiple DNA sequences simultaneously. The method involves amplification of multiple sequences simultaneously by annealing a plurality of paired oligonucleotide primers to single stranded DNA. One member of each pair is complementary to the sense strand of a sequences and the other member is complementary to a different segment of the anti-sense strand of the same sequence. The amplification occurs by alternately annealing and extending the primers. The invention also includes oligonucleotide primer sequences helpful in detecting genetic diseases and/or exogenous DNA sequences.

6015675, Jan 18, 2000

May 11, 1998

9/075967

Charles Thomas Caskey - Houston TX
Richard A. L. Gibbs - Houston TX

Baylor College of Medicine - Houston TX

C12Q 168, C12P 1934, C07H 2102, C07H 2104

435 6

The present invention relates to a process for the rapid and simple detection of mutations in DNA and differences between DNA sequences. This competitive oligonucleotide priming system can be used for the detection of any differences between DNA sequences for which a DNA sequence is known.