CHARLES R MARTIN
Psychologist at 42 Rd, Gainesville, FL

7122152, Oct 17, 2006

Apr 24, 2001

09/842204

Nathan S. Lewis - La Canada CA, US
Michael S. Freund - Altadena CA, US
Shawn M. Briglin - Pasadena CA, US
Phil Tokumaru - Moorpark CA, US
Charles R. Martin - Gainesville FL, US
David T. Mitchell - Gainesville FL, US

University of Florida - Gainesville FL
The California Institute of Technology - Pasadena CA
Aerovironment, Inc. - Monrovia CA

C12Q 1/68, B01N 15/06, B01N 33/00, B01N 33/48, B32B 5/02

422 50, 422 681, 422 81, 422 82, 422 8201, 422 8202, 422 83, 422 98, 422100, 422101, 73 101, 73 102, 73 232, 73 5301, 436 43, 436149, 29592, 295921

Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels can be formed between one or more substrate plates. Sensor can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.

7708871, May 4, 2010

Sep 24, 2003

10/528520

Zuzanna Siwy - Darmstadt, DE
Jan Behrends - Munich, DE
Niels Fertig - Munich, DE
Andrzej Fulinski - Cracow, PL
Charles R Martin - Gainesville FL, US
Reinhard Neumann - Dossenheim, DE
Christina Trautmann - Darmstadt, DE
Eugenia Toimil Molares - Darmstadt, DE

Gesellschaft fuer Schwerionenforschung mbH - Darmstadt

G01N 27/447, G01N 27/453

204450, 204600

The present invention relates to an apparatus having a nanodevice () for controlling the flow of charged particles in an electrolyte. Such apparatus comprises an electrolytic bath container () divided by a polymeric membrane foil () into a first () and a second compartment (), wherein each compartment () comprises an electrode () connected to a voltage supply (). Further the apparatus comprises at least one asymmetric pore () forming a via hole through said foil (), wherein said pore () provides a narrow opening () of a diameter in the range of several nanometers down to about one nanometer on a front side () of said foil () and a wide opening () in the range of several ten nanometers up to several hundred nanometers on a back side () of said foil (). Further, the apparatus comprises an electrically conductive layer () surrounding said narrow opening () on said front side () and a gate voltage supply () connected to said electrically conductive layer () on said front side () of said foil () controlling the flow of charged particles within said nanodevice () from said first compartment () to said second compartment () vice versa. The invention further relates to a method for producing such a nanodevice ().

2004005, Mar 25, 2004

Sep 25, 2002

10/254947

Zuzanna Siwy - Darmstadt, DE
Jan Behrends - Munchen, DE
Niels Fertig - Munchen, DE
Andrzej Fulinski - Cracow, PL
Charles Martin - Gainesville FL, US
Reinhard Neumann - Dossenheim, DE
Christina Trautmann - Darmstadt, DE
Eugenia Molares - Darmstadt, DE

C25D017/00

204/252000, 205/221000, 205/223000

The present invention relates to an apparatus having a nanodevice for controlling the flow of charged particles in an electrolyte. Such apparatus comprises an electrolytic bath container divided by a polymeric foil into a first and a second compartment, wherein each compartment comprises an electrode connected to a voltage supply. Further the apparatus comprises at least one asymmetric pore forming a via hole through said foil, wherein said pore provides a narrow opening of a diameter in the range of several nanometers down to about one nanometer on a front side of said foil and a wide opening in the range of several ten nanometers up to several hundred nanometers on a back side of said foil. Further, the apparatus comprises an electrically conductive layer surrounding said narrow opening on said front side and a gate voltage supply connected to said electrically conductive layer on said front side of said foil controlling the flow of charged particles within said nanodevice from said first compartment to said second compartment vice versa. The invention further relates to a method for producing such a nanodevice.

7595023, Sep 29, 2009

Jul 20, 2006

11/490732

Nathan S. Lewis - La Canada CA, US
Michael S. Freund - Winnipeg, CA
Shawn S. Briglin - Chittenango NY, US
Phillip Tokumaru - Moorpark CA, US
Charles R. Martin - Gainesville FL, US
David Mitchell - Newtown PA, US

The California Institute of Technology - Pasadena CA
University of Florida - Gainesville FL
Aerovironment, Inc. - Monrovia CA

C12Q 1/68

422 62, 422 681, 422 88, 436 55

Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels can be formed between one or more substrate plates. Sensor can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.

2008002, Jan 31, 2008

Sep 29, 2005

11/664339

Charles Martin - Gainesville FL, US
Zuzanna Siwy - Irvine CA, US
Punit Kohli - Gainesville FL, US
Lacramioara Trofin - Murrysville PA, US
C. Harrell - Redwood City CA, US

C12M 1/34, B01J 19/00, G01N 21/01, G01N 27/00

422082010, 422068100, 422082050, 422082090, 435287100

The subject invention provides novel and efficacious systems and methods for particle, chemical, and/or biocompound sensing. In one embodiment, the system of the invention comprises a sensing device that includes a membrane containing at least one nanochannel that spans all or substantially all of the thickness of the membrane. The nanochannel(s) of the invention can be functionalized to enhance target analyte detection and quantification. In one embodiment, the nanochannel is conically shaped and includes a molecular recognition agent for a target analyte. In certain operations, the sensing systems of the invention quantitatively and qualitatively detect biochemical/biomedical species and biomacromolecules, such as proteins, DNA, cells, spores and viruses, with a high degree of sensitivity and specificity.

7928208, Apr 19, 2011

May 9, 2006

11/912902

Charles R. Martin - Gainesville FL, US
Shifeng Hou - Springfield MO, US

University of Florida Research Foundation, Inc. - Gainesville FL

C07H 21/04, C12Q 1/68, C12M 1/36

536 231, 435 6, 435174, 977704, 977742, 977745, 977746

A method of forming DNA nanotubes composed entirely or predominantly from DNA that, The methods of the present invention form single layer or multilayer template-synthesized nanotubes where the bulk of the tube is composed of DNA, and the layers are held together by hybridization of complementary DNA strands. The DNA molecules making up these tubes may be varied as desired, and the DNA is capable of being released from the tube.

7195780, Mar 27, 2007

Oct 21, 2002

10/274829

Donn M. Dennis - Gainesville FL, US
Charles R. Martin - Gainesville FL, US
Richard J. Rogers - Gainesville FL, US
Jon D. Stewart - Gainesville FL, US

University of Florida - Gainesville FL

A61K 9/14, A61K 9/50, B32B 5/16

424502, 424489, 424501, 4284022, 42840222

The invention relates to the nanotubes of various sizes and composed of a wide variety of materials, or combination of materials. The invention also describes the use of such nanotubes for the delivery of various payloads and, in particular, for the in vivo delivery of bioactive substances.