Inventors:
Charles R. Bridges - Charlotte NC, US
Hansell H. Stedman - Norristown PA, US
Charles Yarnall - Lafayette Hill PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61M 37/00, A61M 29/00, A61M 31/00, A61N 1/30
US Classification:
604 401, 604 21, 604509, 604 9601
Abstract:
A perfusion circuit and a use thereof for delivering a substance to a subject's heart in situ during cardiopulmonary bypass surgery are provided. The perfusion circuit defines a path for re-circulating a solution containing a macromolecular complex through a coronary circulation circuit through a subject's heart during a surgical procedure in which the substance is prevented from being delivered to the subject's other organs.