Inventors:
Yusuf A. Hannun - Chapel Hill NC
Alicja Bielawska - Apex NC
Charles McKay - Wilmington DE
Assignee:
Duke University - Durham NC
International Classification:
A61K 3170
Abstract:
The present invention relates, in general, to the bioeffector molecule ceramide and, in particular, to methods of effecting intracellular accumulation of ceramide. The invention further relates to methods of selecting compounds that inhibit alkaline ceramidase and that can be used to treat diseases/disorders associated with cell hyperplasia or dedifferentiation.