Inventors:
Charles N.S. Soparkar - Houston TX, US
International Classification:
A61K 33/30, A61P 17/02, A61P 37/00, A61P 15/10, A61K 38/46, A61K 31/315, A61K 38/16, A61K 9/127
US Classification:
424450, 424 946, 424641, 514494, 514 177
Abstract:
Methods and compositions are provided for increasing responsiveness to therapeutic metalloproteases including increasing and/or maximizing responsiveness and preventing botulinum and tetanus toxin resistance due to a functional deficiency of zinc. Also provided are methods for zinc replacement or supplement in lacking individuals comprising the administration of a zinc supplement for a loading period and/or administration of a phytase supplement together with the zinc supplement. Also provided are methods for standardization of botulinum toxin potency assays that provide for greater certainty and margins of safety in the use of products from different manufacturers.