DR. CHARLES M. CARPENTER, M.D.
Osteopathic Medicine at Campus Dr, Scarborough, ME

6551842, Apr 22, 2003

Mar 14, 2000

09/525151

Charles R. Carpenter - Scarborough ME

IDEXX Laboratories, Inc. - Westbrook ME

G01N 33533

436518, 435 71, 435 79, 4352871, 4352872, 4352877, 4352865, 435810, 435910, 436528, 436530, 436541, 422 681, 422 70, 422 90

A disposable, dry chemistry analytical system is disclosed which is broadly useful for the detection of a variety of analytes present in biological fluids such as whole blood, serum, plasma, urine and cerebral spinal fluid. The invention discloses the use of the reaction interface that forms between two liquids converging from opposite directions within a bibulous material. The discovery comprises a significant improvement over prior art disposable, analytical reagent systems in that the detectable reactant zone is visually distinct and separate from the unreacted reagents allowing for the use of reaction indicators exhibiting only minor changes as well as extremely high concentrations of reactants. In addition, staged, multiple reagents can be incorporated. Whole blood can be used as a sample without the need for separate cell separating materials.

6602719, Aug 5, 2003

Mar 26, 1999

09/277715

Charles Carpenter - Scarborough ME

IDEXX Laboratories, Inc. - Westbrook ME

G01N 33553

436518, 436528, 436530, 436541, 435 71, 435 79, 4352871, 4352872, 4352877, 4352865, 435810, 435970, 422 681, 422 70, 422 99

A disposable, dry chemistry analytical system is disclosed which is broadly useful for the detection of a variety of analytes present in biological fluids such as whole blood, serum, plasma, urine and cerebral spinal fluid. The invention discloses the use of the reaction interface that forms between two liquids converging from opposite directions within a bibulous material. The discovery comprises a significant improvement over prior art disposable, analytical reagent systems in that the detectable reactant zone is distinct and separate from the unreacted reagents allowing for the use of reaction indicators exhibiting only minor changes as well as extremely high concentrations of reactants. In addition, staged, multiple reagents can be incorporated. Whole blood can be used as a sample without the need for separate cell separating materials.

6413778, Jul 2, 2002

Jan 21, 1999

09/235124

Charles R. Carpenter - Scarborough ME
Melanie Tornberg - South Berwick ME
Genevieve Clark - Standish ME

Idexx Laboratories - Westbrook ME

G01N 3348

436 4, 436164, 436177, 435 4, 435 28, 422 55, 422 56, 422 61

The present invention relates to devices, methods and kits for the detection and identification of crystals which may be present in a biological fluid, such as urine from a cat. The device may include a filter and an absorbent material. The fluid may be transferred onto the filter, and fluid passes through the filter and into the absorbent material, thereby isolating crystals on a surface of or within the structure of the filter or membrane. The crystals are then available for staining which will reveal a determining component of the crystals. The device may also include a member for inhibiting backflow from the absorbent material to the filter. The present invention also provides methods for detecting and identifying crystals which may be present in biological fluids. The methods include the steps of isolating the crystals on the surface of or within the structure of a filter or membrane, and contacting the crystals with an indicator which is specific for a determining component of the crystals type. Also provided are kits which include the devices of the present invention, and reagents and other materials necessary to conduct the methods of the present invention.

6601006, Jul 29, 2003

Dec 22, 2000

09/746821

Charles R. Carpenter - Scarborough ME
Diana N. Sands - Bath ME
Karen E. Plante - Limington ME
Brent M. Nelson - Westbrook ME

Idexx Laboratories, Inc. - Westbrook ME

G01F 2500

702104, 702 22, 702 30

The present invention provides methods for the calibration of detection and/or quantification assays for a wide variety of analytes in wet or dry chemistry assay systems. The invention involves the use of a reagent and calibrator, which provide a detectable signal after reacting with the analyte to be assayed for. In preferred embodiments the calibrator is provided in gross excess. A mathematical relationship is provided that relates a reaction measurement of the analyte sample with the reagent and a reaction measurement of the calibrator with the reagent as an equation that defines a three dimensional surface. This relationship may be used to calibrate the detection and/or quantification assay.

7384778, Jun 10, 2008

Jan 9, 2003

10/340569

Chun-Ming Chen - Falmouth ME, US
Charles Carpenter - Scarborough ME, US
Haoyi Gu - Yarmouth ME, US
Ali Naqui - Falmouth ME, US
Gary Madsen - Falmouth WI, US
Thomas O'Connor, Jr. - Westbrook ME, US
Katherine Jean Esty - Westbrook ME, US

Idexx Laboratories, Inc. - Westbrook ME

C12M 1/34, C12Q 1/04

4352871, 435 34

The present invention provides devices and methods for determining the presence or absence of pathogens in a biological sample and for the concurrent determination of the antimicrobial susceptibility of pathogens present. The devices and methods of the present invention are able to make the determinations without pre-selection of target bacteria. Instead, all organisms from the sample are applied to the device. In wells where one or more antimicrobial agents are present only pathogens resistant to the antimicrobial agent grow. This allows the user to determine the presence of target pathogens and concurrently determine the resistance patterns of the organisms without the need to subculture the organisms. The present invention also provides methods of performing a business service of performing the determinations described above, and kits containing the devices and descriptions of the methods.

6893880, May 17, 2005

Apr 27, 2001

09/843961

Charles Carpenter - Scarborough ME, US

IDEXX Laboratories - Westbrook ME

G01N033/53

436514, 436524, 436810, 436518, 435 71, 4352877, 4352881, 4352882, 435970, 422 56, 422 58

The present invention provides a method and a device that utilizes capillarity-mediated, chromatographic transport, for the qualitative or semi-quantitative analysis of selected analytes in liquid samples. The device utilizes an applicator/collection device for collecting and administering the sample to the flow path such that reagent(s) flow through the applicator/collection device, washing the sample into the reaction pathway. The device further utilizes an air gap between the initial location of the reagent and the reaction pathway to funnel the reagent efficiently through the sample so as to collect all or substantially all of the sample and make it available for the reaction(s).

6235539, May 22, 2001

Jun 26, 1998

9/105822

Charles Carpenter - Scarborough ME

IDEXX Laboratories, Inc. - Westbrook ME

G01N 33533

436514

The present invention provides a method and a device that utilizes capillarity-mediated, chromatographic transport, for the qualitative or semi-quantitative analysis of selected analytes in liquid samples. The device utilizes an applicator/collection device for collecting and administering the sample to the flow path such that reagent(s) flow through the applicator/collection device, washing the sample into the reaction pathway. The device farther utilizes an air gap between the initial location of the reagent and the reaction pathway to funnel the reagent efficiently through the sample so as to collect all or substantially all of the sample and make it available for the reaction(s).

7566573, Jul 28, 2009

Dec 19, 2005

11/311567

Charles R. Carpenter - Scarborough ME, US
Giosi Farace - Georgetown ME, US
Paul Scott MacHenry - Portland ME, US
Brian John Foster - Portland ME, US
Michael Ryan D'Angelo - Scarborough ME, US

Idexx Laboratories, Inc. - Westbrook ME

G01N 33/541, G01N 33/533, G01N 33/543

436540, 435 71, 436518

A method and a kit for determining the presence or amount of analytes in samples over a broad potential concentration range for the analyte. The method and kit incorporate chemiluminescent and fluorescent labels conjugated to a specific binding partner for the analyte for sandwich assays, or to the analyte or an analog of the analyte for competitive assays. The conjugates are mixed with the sample and the labels are detected simultaneously or sequentially.

2007026, Nov 22, 2007

May 19, 2006

11/437203

Charles R. Carpenter - Scarborough ME, US
Giosi Farace - Georgetown ME, US

G01N 33/53

435 792

A method for the determination of analytes in samples using a pre-precipitated antibody complex. The complex includes an anti-analyte antibody and a secondary binding molecule that results in the precipitation of the antibody. Labeled-analyte analog competes for binding sites on the complex with analyte in the sample. The presence or amount of the analyte in the sample can is determined by detecting the amount of the label associated with the complex. The pre-precipitated antibody complex may be preloaded with labeled-analyte analog.

5620895, Apr 15, 1997

May 30, 1995

8/454071

Ali Naqui - Falmouth ME
Mark W. Pierson - Saco ME
Thomas R. Weschler - Cape Elizabeth ME
Stephen C. Wardlaw - Old Saybrook CT
Michael P. Finnerty - Auburn ME
Charles R. Carpenter - Scarborough ME

Idexx Laboratories, Inc. - Westbrook ME

C12M 140

4352882

An article adapted for holding a liquid sample for quantification of biological material in the liquid sample. The article includes a bag having an upper surface sheet and a lower surface sheet enclosing a volume therebetween. The bag has an upper opening through which the liquid sample can be poured into the volume in the bag. The bag also has a plurality of partitions configured to separate one or more portions of adequate sample in the bag. Also provided is a passage through which a liquid sample can be distributed throughout the volume in the bag. The bag is made of material which can be caused to form discreet non-permeable compartments for holding separate aliquots of the liquid sample.