Inventors:
Kimberly Ann Griswold - Bloomfield NJ, US
Charles J. Prestigiacomo - East Hanover NJ, US
International Classification:
A61K 9/10, A61K 31/175, A61K 31/704, A61K 31/407, A61K 31/513, A61K 31/519, A61K 31/255, A61K 33/24, A61K 31/17, A61K 31/337, A61K 31/437, A61K 31/52, A61P 7/04, A61P 7/00, A61P 35/00
US Classification:
424486, 424484, 514589, 514 34, 514410, 514274, 514249, 514517, 424649, 514588, 514449, 514286, 5142633
Abstract:
Biodegradable resorbable drug delivery systems characterized by an electrospun biodegradable resorbable polymeric fiber matrix with at least one therapeutic agent incorporated into the fibers of the matrix, wherein the fiber matrix has an interfibrillar space of at least 65% by volume. Therapeutic methods for delivering a chemotherapeutic agent to body cavities from which a tumor has been excised and for strengthening weakened blood vessel walls are also disclosed.