Inventors:
David R. Phillips - San Mateo CA, US
Patrick Andre - San Mateo CA, US
Charles J. Homcy - San Francisco CA, US
Assignee:
Portola Pharmaceuticals, Inc. - South San Francisco CA
International Classification:
A61K 31/4365, A61K 31/422, A61K 31/4406, A61K 31/18, A61K 31/444, A61K 31/192, A61K 31/403, A61P 9/00
US Classification:
514301, 514374, 514357, 514604, 514332, 514570, 514411, 514603
Abstract:
The present invention provides methods and compositions useful in the treatment or prevention of cardiovascular disorders in individuals for whom therapy with a COX-1 enzyme inhibitor is not feasible due to sensitivity, intolerance, or resistance to the inhibitor. Additionally, the invention provides methods of treating cardiovascular disorders in an individual who is receiving a therapeutically effective dose of a TP modulator and is instructed or advised to avoid and/or not to take aspirin or another COX-1 inhibitor.