Inventors:
Michael Brown - North East MD, US
Dale Onisk - Bear DE, US
James Stave - Bear DE, US
Yichun Xu - Newark DE, US
David Johnson - Owensboro KY, US
Charles Melander - Owensboro KY, US
International Classification:
C12Q001/68, C07K016/00
Abstract:
Haptens, ligands (including antibodies), immunoassays, and test kits for detecting tobacco-specific nitrosamines (TSNAs) in samples such as tobacco products are provided. The hapten is a molecule that contains one or more structural characteristics of one or more TSNAs, and is bound to an immunogenic carrier. An antibody specific for one or more TSNAs is produced by immunizing an animal with the hapten bound to the carrier. Immunoassays and test kits using those antibodies are also provided.