Inventors:
Charles D. Smith - Charleston SC, US
Kevin J. French - Harrisburg PA, US
Yan Zhuang - Hershey PA, US
Assignee:
Apogee Biotechnology Corporation - Hershey PA
International Classification:
C07D 211/68, C07D 211/80, A01N 43/40, A61K 31/435
Abstract:
The invention relates to substituted adamantane compounds, pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease.