Inventors:
Charles Eberhart - Baltimore MD, US
Xing Fan - Lutherville MD, US
Anirban Maitra - Baltimore MD, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
A61K 31/381, A61P 35/00, A61K 31/5513, A61K 49/00, A61K 38/43, A61K 39/395, A61K 39/00, A61P 35/02
US Classification:
424 92, 514445, 514221, 424 941, 4241301, 4241841
Abstract:
Provided are methods for treating cancer in a patient, comprising administering to a patient in need thereof a therapeutically effective regimen, the regimen comprising administering a gamma-secretase inhibitor, wherein the regimen results in a reduction in the cancer cell population in the patient. In some embodiments of the methods, the therapeutically effective regimen stabilizes, reduces or eliminates the cancer stem cell population.Also provided are compounds of the formula Ior a pharmaceutically acceptable salt thereof, wherein R, R, and X are as herein described.