Inventors:
Elif A. Oral - Ann Arbor MI, US
Charles F. Burant - Ann Arbor MI, US
Thomas L. Chenevert - Ann Arbor MI, US
Hero K. Hussain - Ann Arbor MI, US
Barbara J. McKenna - Ann Arbor MI, US
Assignee:
University of Michigan - Ann Arbor MI
International Classification:
A61K 38/22, A61P 3/06
Abstract:
The invention generally relates to the use of leptin in the treatment of a leptin-responsive disease or condition in a non-lipodystrophic subject. More particularly, the invention is directed to the use of leptin in the treatment of a fatty liver disease in a non-lipodystrophic subject with a relative leptin deficiency. The invention includes methods for the treatment of nonalcoholic steatohepatitis (NASH), alcoholic fatty liver disease (AFLD), and nonalcoholic fatty liver disease (NAFLD) in a non-lipodystrophic subject. The invention includes the treatment of conditions ranging from ectopic lipid accumulation (steatosis) to cirrhosis.