Inventors:
Jean A. Setterstrom - Alpharetta GA, US
John E. Van Hamont - Fort Meade MD, US
Robert H. Reid - Kensington MD, US
Elliot Jacob - Silver Spring MD, US
Ramasubbu Jeyanthi - Columbia MD, US
Edgar C. Boedeker - Chevy Chase MD, US
Charles E. McQueen - Olney MD, US
Daniel L. Jarboe - Silver Spring MD, US
Frederick Cassels - Ellicott City MD, US
William Brown - Denver CO, US
Curt Thies - Ballwin MO, US
Thomas R. Tice - Birmington AL, US
F. Donald Roberts - Dover MA, US
Phil Friden - Bedford MA, US
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
A61K 950
US Classification:
424501, 424486, 424499, 424422, 424491, 424493, 424426, 514570, 514 2, 514 12, 530350, 530300
Abstract:
Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group, and end-capped forms ranging in ratios from 100/0 to 1/99.