CHARLES E RUPPRECHT
Veterinary in Lawrenceville, GA
License number
Pennsylvania BV005807L
Category
Veterinary Medicine
Type
Veterinarian
Address
Address
2
Lawrenceville, GA 30044
Pennsylvania
Pennsylvania
Personal information
See more information about CHARLES E RUPPRECHT at radaris.comName
Address
Phone
1180 Mckelvey Ln, Blue Bell, PA 19422
133 Knox St, Bridgeville, PA 15017
204 Fairmeadow Cir, Houston, PA 15342
647 Michelle Ct, Lawrenceville, GA 30044
133 Knox St, Bridgeville, PA 15017
Professional information
Rabies Virus-Based Recombinant Immunocontraceptive Compositions And Methods Of Use
US Patent:
8524247, Sep 3, 2013
Filed:
Aug 20, 2009
Appl. No.:
13/062680
Inventors:
Xianfu Wu - Atlanta GA, US
Charles Rupprecht - Lawrenceville GA, US
Charles Rupprecht - Lawrenceville GA, US
Assignee:
The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention - Washington DC
International Classification:
A61K 39/12, C12N 7/01, A61P 37/00
US Classification:
4242051, 4352351
Abstract:
Described herein are recombinant rabies viruses comprising a heterologous nucleic acid sequence encoding an immunocontraceptive protein, such as gonadotropin-releasing hormone (GnRH) or zona pellucida 3 (ZP3). The recombinant rabies viruses disclosed herein are recovered by reverse genetics, replicate efficiently, elicit rabies virus neutralizing antibodies and immunocontraceptive peptide-specific antibodies in vaccinated animals, and protect vaccinated animals against wild-type rabies virus challenge. Further provided is a method of immunizing a non-human animal against rabies virus infection and simultaneously inhibiting fertility of the animal, comprising administering an immunogenic composition comprising one or more of the recombinant rabies viruses described herein.
Genetically Engineered Rabies Recombinant Vaccine For Immunization Of Stray Dogs And Wildlife
US Patent:
7074413, Jul 11, 2006
Filed:
Mar 23, 2001
Appl. No.:
09/816531
Inventors:
Bernhard Dietzschold - Newtown Square PA, US
D. Craig Hooper - Medford NJ, US
Matthias Schnell - Harleysville PA, US
Charles E. Rupprecht - Lawrenceville GA, US
D. Craig Hooper - Medford NJ, US
Matthias Schnell - Harleysville PA, US
Charles E. Rupprecht - Lawrenceville GA, US
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A61K 39/12
US Classification:
4241991, 4242241, 4352351, 435236
Abstract:
Live, attenuated recombinant rabies virus vaccines are generated using reverse genetics to combine the antigenic determinants that render the rabies virus non-pathogenic with the determinants that are responsible for the elicitation of an effective anti-rabies immune response. These vaccines do not affect the antigenic, and therefore the immunogenic, properties of the virus. The present invention further relates to recombinant rabies virus vaccines that express a pro-apoptotic protein, such as cytochrome c, to increase the capacity to induce apoptosis, thereby enhancing the protective immunity against rabies. This new generation of live rabies virus vaccines represents a safe and effective approach to the eradication of rabies in wildlife, and subsequently humans and livestock.
Human Antibodies Against Rabies And Uses Thereof
US Patent:
8226952, Jul 24, 2012
Filed:
Apr 26, 2010
Appl. No.:
12/767182
Inventors:
Donna M. Ambrosino - Jamaica Plain MA, US
Robert Mandell - Collins IA, US
Susan Sloan - Watertown MA, US
Gregory J. Babcock - Marlborough MA, US
Charles Rupprecht - Lawrenceville GA, US
Robert Mandell - Collins IA, US
Susan Sloan - Watertown MA, US
Gregory J. Babcock - Marlborough MA, US
Charles Rupprecht - Lawrenceville GA, US
Assignee:
University of Massachusetts - Boston MA
Centers for Disease Control and Prevention - Atlanta GA
Centers for Disease Control and Prevention - Atlanta GA
International Classification:
A61K 39/42, A61K 39/205
US Classification:
4241591, 4242241, 435 5
Abstract:
Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
Rabies Virus Vector Systems And Compositions And Methods Thereof
US Patent:
2011007, Mar 24, 2011
Filed:
Nov 30, 2010
Appl. No.:
12/956949
Inventors:
Charles E. Rupprecht - Lawrenceville GA, US
Xianfu Wu - Atlanta GA, US
Xianfu Wu - Atlanta GA, US
International Classification:
A61K 39/205, C12N 15/63, C07H 21/02, C12N 7/00, A61P 37/04, A61P 31/14
US Classification:
4242241, 4353201, 536 2372, 4352351
Abstract:
Rabies Virus compositions and methods are provided. The full-length sequence of Rabies Virus strain Evelyn-Rokitnicki-Abelseth (ERA) is disclosed. A reverse genetics system for producing recombinant ERA virus and derivatives thereof is provided, along with compositions including ERA and/or ERA derivative strain viruses, nucleic acids and/or proteins. In some instances, the compositions are immunogenic compositions useful for the pre- or post-exposure treatment of Rabies Virus.
Human Antibodies Against Rabies And Uses Thereof
US Patent:
2013003, Feb 14, 2013
Filed:
Jul 19, 2012
Appl. No.:
13/553564
Inventors:
Donna M. Ambrosino - Jamaica Plain MA, US
Robert Mandell - Collins IA, US
Susan Sloan - Watertown MA, US
Gregory J. Babcock - Marlborough MA, US
Charles Rupprecht - Lawrenceville GA, US
Robert Mandell - Collins IA, US
Susan Sloan - Watertown MA, US
Gregory J. Babcock - Marlborough MA, US
Charles Rupprecht - Lawrenceville GA, US
Assignee:
Center for Disease Control and Prevention - Atlanta GA
University of Massachusetts - Boston MA
University of Massachusetts - Boston MA
International Classification:
C07K 16/10, C12P 21/08, A61P 31/14, A61K 39/42
US Classification:
4241591, 5303883, 53038815, 5303873, 435 696
Abstract:
Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
Pan-Lyssavirus Vaccines Against Rabies
US Patent:
2013009, Apr 18, 2013
Filed:
Jun 23, 2011
Appl. No.:
13/806622
Inventors:
Xianfu Wu - Atlanta GA, US
Charles E. Rupprecht - Lawrenceville GA, US
Ivan V. Kuzmin - Lilburn GA, US
Charles E. Rupprecht - Lawrenceville GA, US
Ivan V. Kuzmin - Lilburn GA, US
Assignee:
The Government of the United States of America as Represented by the Secretary of the Department of - Atlanta GA
International Classification:
A61K 39/205
US Classification:
4242241, 4352351, 4353201, 435352
Abstract:
Described herein are recombinant rabies viruses encoding rabies virus glycoprotein and at least one heterologous glycoprotein from another such as Mokola virus, Lagos bat virus and/or West Caucasian bat virus. In particular embodiments, the recombinant rabies virus includes two or three heterologous glycoproteins. The disclosed recombinant rabies viruses can be used as pan-vaccines to provide protection against that cause rabies.
Human Antibodies Against Rabies And Uses Thereof
US Patent:
7727532, Jun 1, 2010
Filed:
Aug 2, 2007
Appl. No.:
11/890317
Inventors:
Donna M. Ambrosino - Jamaica Plain MA, US
Robert Mandell - Collins IA, US
Susan Sloan - Jamaica Plain MA, US
Gregory J. Babcock - Marlborough MA, US
Charles Rupprecht - Lawrenceville GA, US
Robert Mandell - Collins IA, US
Susan Sloan - Jamaica Plain MA, US
Gregory J. Babcock - Marlborough MA, US
Charles Rupprecht - Lawrenceville GA, US
Assignee:
University of Massachusetts - Boston MA
Centers for Disease Control and Prevention - Atlanta GA
Centers for Disease Control and Prevention - Atlanta GA
International Classification:
A61K 39/42, A61K 39/205
US Classification:
4241591, 4242241
Abstract:
Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
Rabies Virus Vector Systems And Compositions And Methods Thereof
US Patent:
7863041, Jan 4, 2011
Filed:
Oct 13, 2006
Appl. No.:
12/090083
Inventors:
Charles E. Rupprecht - Lawrenceville GA, US
Xianfu Wu - Atlanta GA, US
Xianfu Wu - Atlanta GA, US
Assignee:
The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention - Washington DC
International Classification:
C12N 15/00, A61K 39/205
US Classification:
4353201, 4242241
Abstract:
Rabies Virus compositions and methods are provided. The full-length sequence of Rabies Virus strain Evelyn-Rokitnicki-Abelseth (ERA) is disclosed. A reverse genetics system for producing recombinant ERA virus and derivatives thereof is provided, along with compositions including ERA and/or ERA derivative strain viruses, nucleic acids and/or proteins. In some instances, the compositions are immunogenic compositions useful for the pre- or post-exposure treatment of Rabies Virus.