CHARLES DAI LIN LEE
Engineering in Arlington, MA
License number
Massachusetts 15349
Issued Date
Sep 23, 1994
Type
Engineer in Training
Address
Address
Arlington, MA 02174
Personal information
See more information about CHARLES DAI LIN LEE at radaris.comName
Address
Phone
50 S Huntington Ave APT 3, Jamaica Plain, MA 02130
901 Dedham St, Newton Center, MA 02459
78 Varnum St, Arlington, MA 02474
257 Northampton St UNIT 411, Boston, MA 02118
20 Chapel St APT C508, Brookline, MA 02446
Professional information
Fiber-Coupled Multiplexed Confocal Microscope
US Patent:
6747795, Jun 8, 2004
Filed:
Jun 20, 2001
Appl. No.:
09/885576
Inventors:
Charles P. Lin - Arlington MA
Robert H. Webb - Lincoln MA
Robert H. Webb - Lincoln MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
G02B 2106
US Classification:
359385, 385116, 600182
Abstract:
A confocal microscope system that is inherently fiberoptic compatible is described which has line scanning aided image formation. An incoherent fiberoptic bundle maps a line illumination pattern into a dispersible group of separate sources, and then remaps this confocally selected remitted light to the original line. Fibers, not confocal with the illumination, carry light to be rejected from the image back on itself upon double passing, while separate fibers carry light from non-confocal sample planes. The transformation allows efficient rejection of unwanted photons at a slit aperture. The fiber bundle and an objective lens provide a flexible probe for imaging internal tissue for pathological examination on a cellular level.
Optical Devices And Methods For Selective And Conventional Photocoagulation Of The Retinal Pigment Epithelium
US Patent:
8187257, May 29, 2012
Filed:
Oct 31, 2005
Appl. No.:
11/263677
Inventors:
Charles P. Lin - Arlington MA, US
Clemens Alt - Cambridge MA, US
Clemens Alt - Cambridge MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61B 18/20
US Classification:
606 10, 606 4, 606 17, 607 89
Abstract:
The present invention provides devices and methods for applying radiation to the retina of a patient. In one embodiment, an apparatus includes a radiation source for generating a radiation beam suitable for absorption by retinal pigment epithelial cells. One or more optical components are included to direct the beam onto the retina. A scanner is optically coupled to the radiation source to control movement of the beam in two dimensions to allow a scan over the retina. A controller applies control signals to the scanner to adjust beam movement to illuminate a plurality of retinal locations in a temporal sequence according to a predefined pattern. The device can be operated in one mode to effect selective targeting of retinal pigment epithelial cells, or in another mode to effect thermal photocoagulation of the retina.
Methods Of In Vivo Cytometry
US Patent:
7264794, Sep 4, 2007
Filed:
Dec 17, 2004
Appl. No.:
11/016545
Inventors:
Irene Georgakoudi - Acton MA, US
Charles P. Lin - Arlington MA, US
Charles P. Lin - Arlington MA, US
Assignee:
The General Hospital - Boston MA
International Classification:
A61K 49/00
US Classification:
424 91
Abstract:
The present invention provides methods and systems for performing in-vivo flow cytometry to obtain desired information regarding one or more cell types of interest flowing through a subject's circulatory system. In one embodiment of the invention, a portion of the subject's circulating blood is illuminated with radiation having multiple wavelength components, and the backscattered radiation generated in response to the excitation radiation is detected at a plurality of scattering angles and analyzed to derive the desired information.
Methods For In-Vivo Flow Cytometry
US Patent:
8108031, Jan 31, 2012
Filed:
Aug 27, 2007
Appl. No.:
11/895702
Inventors:
Irene Georgakoudi - Acton MA, US
Charles P. Lin - Arlington MA, US
Charles P. Lin - Arlington MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61B 8/14
US Classification:
600476, 600473, 600478, 600467, 424 91
Abstract:
The present invention provides methods and systems for performing in-vivo flow cytometry to obtain desired information regarding one or more cell types of interest flowing through a subject's circulatory system. In one embodiment of the invention, a portion of the subject's circulating blood is illuminated with radiation having multiple wavelength components, and the backscattered radiation generated in response to the excitation radiation is detected at a plurality of scattering angles and analyzed to derive the desired information.
Dose Determination For Inducing Microcavitation In Retinal Pigment Epithelium (Rpe)
US Patent:
2012002, Feb 2, 2012
Filed:
Jan 22, 2010
Appl. No.:
13/145605
Inventors:
Charles P. Lin - Arlington MA, US
Clemens Alt - Watertown MA, US
Ho Lee - Daegu, KR
Clemens Alt - Watertown MA, US
Ho Lee - Daegu, KR
Assignee:
THE GENERAL HOSPITAL CORPORATION - Boston MA
International Classification:
A61F 9/008
US Classification:
606 4
Abstract:
Methods and systems for controlling selective targeting of retinal pigment epithelium (RPE) cells within a treatment region of the RPE. The methods include (a) depositing a selected amount of energy on a test region of the RPE; (b) determining an extent to which microcavitation has occurred in the test region; and (c) on the basis of the determination, either depositing the selected amount of energy on the treatment region, or depositing an increased amount of energy on the test region, and repeating steps (b) and (c).
Fiber-Coupled Multiplexed Confocal Microscope
US Patent:
7292390, Nov 6, 2007
Filed:
Apr 22, 2004
Appl. No.:
10/830905
Inventors:
Charles P. Lin - Arlington MA, US
Robert H. Webb - Lincoln MA, US
Robert H. Webb - Lincoln MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
G02B 21/06
US Classification:
359385, 385116, 600182
Abstract:
A confocal microscope system that is inherently fiberoptic compatible is described which has line scanning aided image formation. An incoherent fiberoptic bundle maps a line illumination pattern into a dispersible group of separate sources, and then remaps this confocally selected remitted light to the original line. Fibers, not confocal with the illumination, carry light to be rejected from the image back on itself upon double passing, while separate fibers carry light from non-confocal sample planes. The transformation allows efficient rejection of unwanted photons at a slit aperture. The fiber bundle and an objective lens provide a flexible probe for imaging internal tissue for pathological examination on a cellular level.
In Vivo Flow Cytometry System And Method
US Patent:
8178342, May 15, 2012
Filed:
Jan 7, 2009
Appl. No.:
12/349612
Inventors:
Charles P. Lin - Arlington MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
C12M 1/34
US Classification:
4352872, 435 721, 435 723, 435 724, 4352865, 436517, 436 56, 436 63, 436 64, 436164, 422 681, 422 73, 422 8208
Abstract:
The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in vivo so as to excite the fluorescent probes, and the radiation emitted by the excited probes is detected, preferably confocally. The detected radiation is then analyzed to derive desired information, such as relative cell count, of the cells of interest.
Retinal Flow Cytometry
US Patent:
2012013, May 31, 2012
Filed:
Jan 25, 2012
Appl. No.:
13/357939
Inventors:
Charles P. Lin - Arlington MA, US
Clemens Alt - Watertown MA, US
Israel Veilleux - Saint-Nicolas, CA
Daniel Cote - Des Charmes, CA
Clemens Alt - Watertown MA, US
Israel Veilleux - Saint-Nicolas, CA
Daniel Cote - Des Charmes, CA
Assignee:
The General Hospital Corporation D/B/A Massachusetts General Hospital - Boston MA
International Classification:
A61B 6/00
US Classification:
600476
Abstract:
The present invention provides methods and devices for performing flow cytometry. In one embodiment, blood circulating through one or more retinal blood vessels of a subject is illuminated in-vivo so as to excite a plurality of fluorescent-labeled cells contained in the blood. The fluorescence radiation emitted by the excited cells is then detected and analyzed to count the cells from which fluorescence is detected.
In-Vivo Monitoring Of Circulating Apoptotic Cells
US Patent:
8211660, Jul 3, 2012
Filed:
May 24, 2010
Appl. No.:
12/785833
Inventors:
Charles P. Lin - Arlington MA, US
Xunbin Wei - Quincy MA, US
Dorothy Sipkins - Evanston IL, US
Xunbin Wei - Quincy MA, US
Dorothy Sipkins - Evanston IL, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
G01N 33/574, A61K 49/00
US Classification:
435 723, 435 721, 435 724, 4352865, 4352872, 436517, 436546, 436 10, 436 56, 436 64, 436164, 436172, 424 91, 424 96, 422 73, 422 8205, 422 8208, 422 8209
Abstract:
The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in-vivo so as to excite the fluorescent probes, and the radiation emitted by the excited probes is detected, preferably confocally. The detected radiation is then analyzed to derive desired information, such as relative cell count, of the cells of interest. In some embodiments, the circulating cells comprise apoptotic cells whose detection can allow, e. g. , non-invasive monitoring of the efficacy of a cancer treatment, such as an anti-tumor or an anti-angiogenic therapy.
In Vivo Flow Cytometry System And Method
US Patent:
7491502, Feb 17, 2009
Filed:
Dec 17, 2004
Appl. No.:
11/015334
Inventors:
Charles P. Lin - Arlington MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
G01N 33/567
US Classification:
435 721, 435 723, 435 724, 4352865, 4352872, 436517, 436546, 436 10, 436 56, 436 63, 436 64, 436164, 424 73
Abstract:
The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in vivo so as to excite the fluorescent probes, and the radiation emitted by the excited probes is detected, preferably confocally. The detected radiation is then analyzed to derive desired information, such as relative cell count, of the cells of interest.