Inventors:
Jeff Stehouwer - Atlanta GA, US
Mark Goodman - Atlanta GA, US
Clint Kilts - Little Rock AR, US
Charles Nemeroff - Coconut Grove FL, US
Assignee:
Emory University - Atlanta GA
International Classification:
A61K 31/4985, C07D 471/04
US Classification:
514249, 544336, 544350, 514247
Abstract:
Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein, methods of imaging, method of forming a compound as described herein, and the like. In particular, embodiments of the disclosure include a series of triamino-pyridine derivatives and labeled triamino-pyridine derivatives, methods of synthesizing these compounds, intermediate compounds, methods of treatment using these compounds, methods of imaging, diagnosing, localizing, monitoring, and/or assessing a condition (e. g. , corticotropin releasing factor type-1 (CRF1)) and/or related biological events, using triamino-pyridine derivatives, and the like. In addition, the present disclosure includes compositions (e. g. , labeled triamino-pyridine derivatives that are ligands for the CRF1 receptor) used in and methods relating to non-invasive imaging (e. g.