Inventors:
Charles A. Stevens - Lansdale PA
Michael R. Hoy - North Wales PA
Edward J. Roche - Paoli PA
Assignee:
McNeil-PPC, Inc. - Skillman NJ
International Classification:
B05D 312, A61K 924, A61J 300
Abstract:
A method of making solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of cimetidine, ranitidine, famotidine, diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier. The barrier is formed by coating with a polymer impermeable to simethicone.