PROF. CHARIS ENG, MD, PHD, FACP
Medical Practice at Euclid Ave, Cleveland, OH
License number
Ohio 35.075398
Category
Medical Practice
Type
Clinical Genetics (M.D.)
Address
Address
9500 Euclid Ave NE-50 CLEVELAND CLINIC GENOMIC MEDICINE INSTITUTE, Cleveland, OH 44195
Phone
(216) 444-3440
(216) 636-0009 (Fax)
(216) 636-0009 (Fax)
Organization information
See more information about CHARIS ENG at bizstanding.comCharis Eng MD,PHD,FACP
9500 Euclid Ave, Cleveland, OH 44106
Industry:
Genetic Medicine, Internist
Phone:
(216) 445-5686 (Phone)
Charis Euli Eng
Professional information
Hardis Chair And Director, Genomic Medicine Institute, Cleveland Clinic
Position:
Hardis Chair and Director at Cleveland Clinic Genomic Medicine Institute, Director at Center for Personalized Genetic Healthcare, Cleveland Cilnic, Professor and Vice Chair, Dept of Genetics and Genome Sciences at Case Western Reserve University
Location:
Cleveland/Akron, Ohio Area
Industry:
Research
Work:
Cleveland Clinic Genomic Medicine Institute
since Sep 2005
-
Hardis Chair and Director
Center for Personalized Genetic Healthcare, Cleveland Cilnic
since Sep 2005
-
Director
Case Western Reserve University
- Cleveland/Akron, Ohio Area since Sep 2005
-
Professor and Vice Chair, Dept of Genetics and Genome Sciences
The Ohio State University Wexner Medical Center
Jul 2002 - Aug 2005
-
Klotz Professor and Director, Division of Human Genetics, Department of Internal Medicine
The Ohio State University
- Columbus, Ohio Area Jul 2002 - Aug 2005
-
Professor of Medicine
The Ohio State University Wexner Medical Center
- Columbus, Ohio Area Jan 1999 - Aug 2005
-
Director, Clinical Cancer Genetics Program
The Ohio State University Wexner Medical Center
Jul 2001 - Jun 2002
-
Davis Professor of Cancer Research
The Ohio State University
- Columbus, Ohio Area Jan 1999 - Jun 2002
-
Associate Professor of Medicine
Dana-Farber Cancer Institute
- Greater Boston Area Oct 1995 - Dec 1998
-
Active Staff Adult Oncologist
Harvard Medical School
- Greater Boston Area Oct 1995 - Dec 1998
-
Assistant Professor of Medicine
The Royal Marsden NHS Foundation Trust
- London, United Kingdom Jan 1993 - Sep 1995
-
Hon. Senior Registrar, Department of Medical Genetics
Addenbrooke's Hospital
- Cambridge, United Kingdom Oct 1992 - Sep 1995
-
Hon. Senior Registrar, Center for Medical Genetics
University of Cambridge
- Cambridge, United Kingdom Sep 1992 - Sep 1995
-
CRC-Dana-Farber Fellow in Clinical Cancer Genetics
Dana-Farber Cancer Institute
- Greater Boston Area Jul 1991 - Jun 1994
-
Medical Oncology Fellow
Harvard Medical School
- Greater Boston Area Jul 1988 - Jun 1994
-
Clinical Instructor in Medicine
Beth Israel Hospital
- Greater Boston Area Jul 1988 - Jun 1991
-
Resident, Department of Internal Medicine
Education:
University of Chicago - The Pritzker School of Medicine 1982 - 1988
Doctor of Medicine (MD), Medicine University of Chicago - The Pritzker School of Medicine 1982 - 1986
PhD, Developmental Biology and Human Genetics University of Chicago 1978 - 1982
BA Honors, Biological Sciences University of Chicago Laboratory Schools 1975 - 1978
Methodist Girls School, Singapore 1969 - 1975
Doctor of Medicine (MD), Medicine University of Chicago - The Pritzker School of Medicine 1982 - 1986
PhD, Developmental Biology and Human Genetics University of Chicago 1978 - 1982
BA Honors, Biological Sciences University of Chicago Laboratory Schools 1975 - 1978
Methodist Girls School, Singapore 1969 - 1975
Interests:
Cancer genetics and integrative omics, clinical cancer genetics, genomics-enabled value-based health care delivery
Honor & Awards:
Phi Beta Kappa
Sigma Xi
Alpha Omega Alpha
American Society of Clinical Investigation, Elected Member
AAAS, Elected Fellow
Association of American Physicians, Elected Member
Institute of Medicine of the National Academies, Elected Member
Targets For Use In Diagnosis, Prognosis And Therapy Of Breast Cancer
US Patent:
8206910, Jun 26, 2012
Filed:
Dec 8, 2009
Appl. No.:
12/633539
Inventors:
Charis Eng - Cleveland Heights OH, US
Assignee:
The Cleveland Clinic Foundation - Cleveland OH
International Classification:
C12P 19/34, C12Q 1/68
US Classification:
435 61, 435 614, 435 912, 436 64
Abstract:
The invention is directed to methods of diagnosing breast cancer, susceptibility to breast cancer, nodal metastasis of a breast cancer and screening for breast cancer in an individual in need thereof comprising detecting the presence of a loss of heterozygosity/allelic imbalance (LOH/AI) at one or more specific loci (markers) in the genome of the individual, wherein the presence of the LOH/AI at the one or more specific loci in the genome of the individual is indicative of a diagnosis of breast cancer in the individual.
Compositions And Methods For Assessing And Treating A Precursor Lesion And/Or Esophageal Cancer
US Patent:
2013019, Jul 25, 2013
Filed:
Jul 26, 2012
Appl. No.:
13/559101
Inventors:
Charis Eng - Cleveland Heights OH, US
International Classification:
C12Q 1/68, C07K 16/18, G01N 33/68, C07K 14/705, C07K 14/47, C07K 16/30
US Classification:
514338, 530350, 536 235, 5303879, 435 611, 436501
Abstract:
One aspect of the present disclosure relates to a method for predicting a subject's risk of developing an esophageal cancer, a precursor lesion, or both. One step of the method includes obtaining a biological sample from the subject. Next, the presence of at least one germline mutation is determined in the biological sample. The subject is at an increased risk of an esophageal cancer, a precursor lesion, or both, where the presence of at least one germline mutation is determined.
Methods And Compositions For Detection Of Cowden Syndrome (Cs) And Cs-Like Syndrome
US Patent:
2012032, Dec 20, 2012
Filed:
Apr 12, 2012
Appl. No.:
13/445688
Inventors:
Charis Eng - Cleveland Heights OH, US
Assignee:
The Cleveland Clinic Foundation - Cleveland OH
International Classification:
C12Q 1/68, G01N 33/573
US Classification:
435 611, 435 74
Abstract:
The invention is directed to methods of detecting Cowden syndrome (CS) or CS-like syndrome in an individual or determining whether an individual is at risk for developing Cowden syndrome (CS) or CS-like syndrome comprising detecting the presence of a mutated succinate dehydrogenase B (SDHB), mutated succinate dehydrogenase D (SDHD) or combination thereof in the individual, wherein detection of a mutated SDHB, SDHD or a combination thereof indicates that the individual is positive for, or at risk of developing, CS or CS-like syndrome. The invention is also directed to an article of manufacture for detecting Cowden syndrome (CS) or Cowden-like syndrome in an individual, comprising one or more agents that detects mutated succinate dehydrogenase B (SDHB), mutated succinate dehydrogenase D (SDHD) or combination thereof in the individual, and instructions for use.
Methods And Compositions For Detection Of Cowden Syndrome (Cs) And Cs-Like Syndrome
US Patent:
2010009, Apr 15, 2010
Filed:
Jul 27, 2009
Appl. No.:
12/462053
Inventors:
Charis Eng - Cleveland Heights OH, US
Assignee:
The Cleveland Clinic Foundation - Cleveland OH
International Classification:
C12Q 1/68, C12Q 1/32
US Classification:
435 6, 435 26
Abstract:
In one aspect, the invention is directed to a method of detecting Cowden syndrome (CS) or CS-like syndrome in an individual comprising detecting the presence of a mutated succinate dehydrogenase B (SDHB), mutated succinate dehydrogenase D (SDHD) or combination thereof in the individual, wherein detection of a mutated SDHB, SDHD or a combination thereof indicates that the individual is positive for CS or CS-like syndrome. In another aspect, the invention is directed to a method of determining whether an individual is at risk for developing Cowden syndrome (CS) or CS-like syndrome comprising detecting the presence of a mutated succinate dehydrogenase B (SDHB), mutated succinate dehydrogenase D (SDHD) or combination thereof in the individual, wherein detection of a mutated SDHB, SDHD or a combination thereof indicates that the individual is at risk for developing for CS or CS-like syndrome. In yet another aspect, the invention is directed to an article of manufacture for detecting Cowden syndrome (CS) or Cowden-like syndrome in an individual, comprising one or more agents that detects mutated succinate dehydrogenase B (SDHB), mutated succinate dehydrogenase D (SDHD) or combination thereof in the individual, and instructions for use.
Targets For Use In Diagnosis, Prognosis And Therapy Of Cancer
US Patent:
2010025, Oct 7, 2010
Filed:
Mar 18, 2010
Appl. No.:
12/727039
Inventors:
Charis Eng - Cleveland Heights OH, US
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
The invention is directed to a method of diagnosing cancer, or susceptibility to cancer, in an individual in need thereof comprising detecting homozygosity at one or more loci of the individual's nucleic acid, wherein the one or more loci is selected from the group consisting of: D2S1790, D3S2427, D4S2394, D5S2505, D6S1959, D7S3046, D9S1871, D10S1222, D11S1993, D11S1986, D11S4463, D13S793, D15S822, GATA178F11, D18S1376, and D20S477, and homozygosity at the one or more loci is indicative of a diagnosis of cancer, or susceptibility to cancer, in the individual. Also provided herein are kits for use in diagnosing cancer or susceptibility to cancer in an individual comprising one or more regents for detecting the presence of a homozygosity at one or more loci selected from the group consisting of: D2S1790, D3S2427, D4S2394, D5S2505, D6S1959, D7S3046, D9S1871, D10S1222, D11S1993, D11S1986, D11S4463, D13S793, D15S822, GATA178F11, D18S1376, and D20S477 and instructions for use.
Disease Risk Decision Support Platform
US Patent:
2013010, Apr 25, 2013
Filed:
Oct 19, 2012
Appl. No.:
13/655816
Inventors:
Charis Eng - Cleveland Heights OH, US
Assignee:
THE CLEVELAND CLINIC FOUNDATION - Cleveland OH
International Classification:
G06Q 50/22
US Classification:
705 2
Abstract:
A system provides a disease specific risk reference and includes a plurality of executable item modules that each define a different elementary disease to family structure relationship for a specific disease represented as a logical Boolean operation, and an item scoring engine that ranks positively scored item modules based on a risk level associated with a corresponding elementary disease to family structure relationship, wherein the positive scores identify an existence of a given disease to family structure relationship. The system further includes a disease specific risk reference generator that extracts item content associated with a subset of the highest ranked positively scored item modules from memory and provides the extracted item content in a disease specific risk reference for review by a clinician.
Diagnosis Of Cowden And Cowden-Like Syndrome By Detection Of Decreased Killin Expression
US Patent:
2013015, Jun 20, 2013
Filed:
Dec 20, 2012
Appl. No.:
13/721696
Inventors:
Charis Eng - Cleveland Heights OH, US
Assignee:
THE CLEVELAND CLINIC FOUNDATION - Cleveland OH
International Classification:
C12Q 1/68
US Classification:
514 192, 435 611
Abstract:
A method of diagnosing Cowden syndrome (CS) and Cowden-like Syndrome (CLS) is described. The method includes diagnosing CS and CLS in a subject by identifying a decrease in expression of the KILLIN gene, or by identifying hypermethylation of the KILLIN promoter region. Kits for diagnosing CS and CLS by identifying subjects having KILLIN promoter region hypermethylation and primers specific for a methylated KILLIN promoter region are also described.
Method For Differentiating Malignant From Benign Thyroid Tissue
US Patent:
7670775, Mar 2, 2010
Filed:
Feb 15, 2007
Appl. No.:
11/675375
Inventors:
Charis Eng - Beachwood OH, US
Frank Weber - Cleveland OH, US
Frank Weber - Cleveland OH, US
Assignee:
The Ohio State University Research Foundation - Columbus OH
International Classification:
C12Q 1/68, G01N 33/53, C07H 21/02, C07H 21/04
US Classification:
435 6, 435 71, 536 231, 536 243
Abstract:
Methods of identifying malignant thyroid tissue comprising testing a thyroid tissue sample for the expression of at least two genes chosen from CCND2, PCSK2, and PLAB. Kits for use in the disclosed methods are also provided.
Targets For Use In Diagnosis, Prognosis And Therapy Of Cancer
US Patent:
8163493, Apr 24, 2012
Filed:
Dec 24, 2008
Appl. No.:
12/343871
Inventors:
Charis Eng - Cleveland Heights OH, US
Frank Weber - Essen, DE
Frank Weber - Essen, DE
Assignee:
The Cleveland Clinic Foundation - Cleveland OH
International Classification:
C12Q 1/68
US Classification:
435 614
Abstract:
Provided herein are targets that can be used for the diagnosis, prognosis and therapy of a variety of cancers.