CARY LANCE QUEEN
Pilots at San Juan Rd, Cupertino, CA
License number
California A4967776
Issued Date
Aug 2016
Expiration Date
Aug 2018
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
22830 San Juan Rd, Cupertino, CA 95014
Professional information
Method For Treating Psoriasis
US Patent:
2013007, Mar 21, 2013
Filed:
Nov 16, 2012
Appl. No.:
13/679022
Inventors:
Kenneth Hong - El Cerrito CA, US
Cary Queen - Cupertino CA, US
Cary Queen - Cupertino CA, US
Assignee:
Abbott Biotherapeutics Corp. - Redwood City CA
International Classification:
A01K 67/027, A61K 39/395
US Classification:
4241331, 4241581, 4241731, 4241451, 4241421, 800 9, 435 71
Abstract:
Methods and compositions are provided for the creation and screening of non-human animal models having many of the histologic characteristics of human psoriasis. Immunocompromised host animals are injected with a purified population of CD45Rb positive cells, which are tolerant of the host major histocompatibility antigens, but are mismatched at one or more minor antigens. The injected cells are stimulated with a pro-inflammatory cytokine, e.g. IL-12, and a polyclonal activating agent. The injected animals develop a chronic skin disorder that includes histological features observed in human psoriasis, e.g. rete pegs, severe acanthosis and infiltration of Th1 cells into the dermis.