Carrolee Barlow
Physician in La Jolla, CA
License number
Utah 184272-1205
Issued Date
Mar 12, 1991
Expiration Date
Apr 30, 2000
Category
Physician
Type
Physician & Surgeon
Address
Address
La Jolla, CA
Professional information
Transgenic Animals At A Nuclear Hormone Receptor Locus
US Patent:
2002013, Sep 19, 2002
Filed:
Mar 16, 2001
Appl. No.:
09/810306
Inventors:
Carrolee Barlow - La Jolla CA, US
Todd Carter - San Diego CA, US
Todd Carter - San Diego CA, US
International Classification:
A01K067/027
US Classification:
800/018000, 800/009000
Abstract:
The present disclosure relates to an inbred non-human transgenic animal having a multimeric nuclear hormone receptor, comprising a thyroid hormone receptor subunit and a nuclear hormone receptor subunit, wherein either or both the thyroid hormone receptor subunit and a nuclear hormone receptor subunits are mutated such that expression of said multimeric nuclear hormone receptor results in a measurable phenotype. The disclosure also contemplates methods of making inbred non-human transgenic animals. Methods of using the disclosed inbred non-human transgenic animals as models for various diseases and for screening small molecules that are determined to be efficacious in the treatment of such diseases are also disclosed.