CARRIE ADELIA SIMS
Medical Practice in Boston, MA
License number
Pennsylvania MT184235
Category
Medicine
Type
Graduate Medical Trainee
Address
Address
2
Boston, MA 02114
Pennsylvania
Pennsylvania
Personal information
See more information about CARRIE ADELIA SIMS at radaris.comName
Address
Phone
414 3Rd Ave, New Brighton, PA 15066
510 N Wynnewood Ave, Wynnewood, PA 19096
10 Emerson Pl APT 12C, Boston, MA 02114
40 Anderson St, Boston, MA 02114
1580 Massachusetts Ave, Cambridge, MA 02138
Professional information
See more information about CARRIE ADELIA SIMS at trustoria.com
Pyruvate Ester Composition And Method Of Use For Resuscitation After Events Of Ischemia And Reperfusion
Pyruvate Ester Composition And Method Of Use For Resuscitation After Events Of Ischemia And Reperfusion
US Patent:
2005005, Mar 17, 2005
Filed:
Sep 23, 2004
Appl. No.:
10/948026
Inventors:
Alfred Ajami - Brookline MA, US
Carrie Sims - Boston MA, US
Mitchell Fink - Pittsburgh PA, US
Carrie Sims - Boston MA, US
Mitchell Fink - Pittsburgh PA, US
Assignee:
Xanthus Life Sciences, Inc. - Montreal
Beth Israel Deaconess Medical Center, Inc. - Boston MA
Beth Israel Deaconess Medical Center, Inc. - Boston MA
International Classification:
A61K031/22, A61K033/06
US Classification:
514546000, 424682000
Abstract:
A therapeutic composition comprising an alkyl, aralkyl, alkoxyalkyl or carboxyalkyl ester of 2ketoalkanoic acid and a component for inducing and stabilizing the enol resonance form of the ester at physiological pH values is disclosed. The composition of the invention further comprises a pharmaceutically acceptable carier vehicle in which the enol resonance form of the ester is stabilized at physiological pH values. Formulations containing the compositions of the invention permit the successful use of 2-ketoalkanoic acid esters, e.g., pyruvic acid esters, to treat, e.g., is chemic events, shock, organ reanimation, resuscitation and other recognized pyruvate-effective treatments. The compositions of the inventions are also useful in a process for preserving organ parts, organs or limbs removed from a living mammal and in need of preservation, e.g., for later transplantation to an organ recipient.
Pyruvate Ester Composition And Method Of Use For Resuscitation After Events Of Ischemia And Reperfusion
Pyruvate Ester Composition And Method Of Use For Resuscitation After Events Of Ischemia And Reperfusion
US Patent:
2003007, Apr 17, 2003
Filed:
Apr 4, 2002
Appl. No.:
10/116707
Inventors:
Alfred Ajami - Brookline MA, US
Carrie Sims - Boston MA, US
Mitchell Fink - Pittsburgh PA, US
Carrie Sims - Boston MA, US
Mitchell Fink - Pittsburgh PA, US
Assignee:
Xanthus Life Sciences, Inc. - Montreal QC
International Classification:
A61K031/22
US Classification:
514/546000
Abstract:
A therapeutic composition comprising an alkyl, aralkyl, alkoxyalkyl or carboxyalkyl ester of 2-ketoalkanoic acid and a component for inducing and stabilizing the enol resonance form of the ester at physiological pH values is disclosed. The composition of the invention further comprises a pharmceutically acceptable carier vehicle in which the enol resonance form of the ester is stabilized at physiological pH values. Formulations containing the compositions of the invention permit the successful use of 2-ketoalkanoic acid esters, e.g., pyruvic acid esters, to treat, e.g., ischemic events, shock, organ reanimation, resuscitation and other recognized pyruvate-effective treatments. The compositions of the inventions are also useful in a process for preserving organ parts, organs or limbs removed from a living mammal and in need of preservation, e.g., for later transplantation to an organ recipient.