DR. CARMEN A PULIAFITO, MD
Medical Practice at 17 Ave, Miami, FL

8319974, Nov 27, 2012

Mar 8, 2011

13/043401

Robert W. Knighton - Miami FL, US
Shuliang Jiao - Miami FL, US
Giovanni Gregori - Coral Gables FL, US
Carmen A. Puliafito - Pinecrest FL, US

Carl Zeiss Meditec, Inc. - Dublin CA

G01B 9/02

356479

A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.

7301644, Nov 27, 2007

Sep 6, 2005

11/219992

Robert W. Knighton - Miami FL, US
Shuliang Jiao - Miami FL, US
Giovanni Gregori - Coral Gables FL, US
Carmen A. Puliafito - Pinecrest FL, US

University of Miami - Miami FL

G01B 9/02

356479

A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.

7505142, Mar 17, 2009

Oct 18, 2007

11/975239

Robert W. Knighton - Miami FL, US
Shuliang Jiao - Miami FL, US
Giovanni Gregori - Coral Gables FL, US
Carmen A. Puliafito - Pinecrest FL, US

University of Miami - Miami FL

G01B 9/02

356479

A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.

7659990, Feb 9, 2010

Feb 4, 2009

12/322607

Robert W. Knighton - Miami FL, US
Shuliang Jiao - Miami FL, US
Giovanni Gregori - Coral Gables FL, US
Carmen A. Puliafito - Pinecrest FL, US

University of Miami - Miami FL

G01B 9/02

356479

A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.

7924429, Apr 12, 2011

Dec 22, 2009

12/644526

Robert W. Knighton - Miami FL, US
Shuliang Jiao - Miami FL, US
Giovanni Gregori - Coral Gables FL, US
Carmen A. Puliafito - Pinecrest FL, US

University of Miami - Miami FL

G01B 9/02

356479

A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.

2006010, May 11, 2006

Oct 5, 2005

11/244244

Giovanni Gregori - Coral Gables FL, US
Carmen Puliafito - Pinecrest FL, US
Robert Knighton - Miami FL, US

A61B 6/00

600476000

A system, method and apparatus for speckle noise removal based upon structural correlation in an OCT imaging system. In accordance with the present invention, several two- or three-dimensional OCT image scans can be acquired for processing by an adaptive algorithm. Specifically, at each image point an image intensity can be computed that quantifies a measure of dispersion of the image values in a particular direction with respect to their mean. Subsequently, a direction θ(x, y) can be selected which minimizes the energy function at the given pixel (x, y). Finally, a value proportional to a local average of the input image around the point (x, y) can be chosen for the output image. In this way speckle noise can be minimized if not removed while, at the same time, maintaining the image substantially free of obvious artifacts.