Inventors:
Carlos Subauste - Solon OH, US
International Classification:
A61K 39/395, A61K 38/02, A61P 29/00, A61P 25/00, A61P 9/10, A61P 3/10, A61P 37/02
US Classification:
4241581, 514 11, 4241841, 514 177, 514 69, 514 19
Abstract:
A method for treating a CD40-mediated disease in a subject includes administering to cells expressing CD40 of the subject a therapeutically effective amount of an agent that inhibits binding of TNF receptor associated factor 2 (TRAF2) to a cytoplasmic portion of CD40.