Inventors:
Carl W. White - Denver CO, US
Assignee:
National Jewish Medical and Research Center - Denver CO
International Classification:
A61K 45/05, A61K 38/00, C07K 13/00
US Classification:
4241851, 424 852, 424450, 514 2, 514 17, 514 18, 514826, 514886, 530329, 530330, 530399
Abstract:
Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. The composition contains a protein or peptide containing a thioredoxin active-site in reduced state and optionally further contains a reducing system.