DR. CARL VIRGIL MANION, M.D.
Marriage and Family Therapists at Sunnymeade Pl, Oklahoma City, OK
License number
Oklahoma 11404
Category
Osteopathic Medicine
Type
Family Medicine
Address
Address
10852 Sunnymeade Pl, Oklahoma City, OK 73120
Phone
(405) 326-5465
(405) 752-9580 (Fax)
(405) 752-9580 (Fax)
Personal information
See more information about CARL VIRGIL MANION at radaris.comName
Address
Phone
6313 Overcourt Mnr, Oklahoma City, OK 73132
6313 Overcourt Mnr, Oklahoma City, OK 73132
Bethany, OK
Professional information
Inhibition Of Allergic Contact Dermatitis By N-L-Alpha-Aspartyl-L-Phenylalanine 1-Methyl Ester
US Patent:
7288527, Oct 30, 2007
Filed:
Apr 14, 2005
Appl. No.:
11/106201
Inventors:
Carl V. Manion - Oklahoma City OK, US
Assignee:
Oklahoma Medical Research Foundation - Oklahoma City OK
International Classification:
C07K 5/06
US Classification:
514 19
Abstract:
It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester (APM) and/or one of its lower alkyl derivatives can be used to treat allergic contact dermatitis associated with irritating oils such as catechol-containing plant-derived antigens such as poison ivy, poison oak, poison sumac and Asian lacquer tree and oils containing capsaicin. Topical application of APM and/or derivative can reduce or alleviate the symptoms associated with irritation of the skin and/or mucous membranes caused by contact or inhalation of these oils or fumes from burning vegetation containing these oils.
Inhibition Of Allergic Contact Dermatitis By N-L-Alpha-Aspartyl-L-Phenylalanine 1-Methyl Ester
US Patent:
7816327, Oct 19, 2010
Filed:
Sep 25, 2007
Appl. No.:
11/861231
Inventors:
Carl V Manion - Oklahoma City OK, US
Assignee:
Oklahoma Medical Research Foundation - Oklahoma City OK
International Classification:
C07K 5/06
US Classification:
514 19
Abstract:
It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester (APM) and/or one of its lower alkyl derivatives can be used to treat allergic contact dermatitis associated with irritating oils such as catechol-containing plant-derived antigens such as poison ivy, poison oak, poison sumac and Asian lacquer tree and oils containing capsaicin. Topical application of APM and/or derivative can reduce or alleviate the symptoms associated with irritation of the skin and/or mucous membranes caused by contact or inhalation of these oils or fumes from burning vegetation containing these oils.
Owner, Carl V Manion
Position:
Owner at Carl V Manion
Location:
Oklahoma City, Oklahoma Area
Industry:
Photography
Work:
Carl V Manion
-
Owner
Education:
University of Colorado 1961 - 1965
Hastings College 1958 - 1961
Hastings College 1958 - 1961
Dr. Carl V Manion - MD (Doctor of Medicine)
Specialties:
Internal Medicine, Clinical Pharmacology
Languages:
English
Hospitals:
10852 Sunnymeade Pl, Oklahoma City 73120
10852 Sunnymeade Pl, Oklahoma City 73120
10852 Sunnymeade Pl, Oklahoma City 73120
Education:
Medical School
University of Colorado At Denver
Graduated: 1965
University of Colorado At Denver
Graduated: 1965
Inhibition Or Erythrocyte Sickling By N-L-Alpha-Aspartyl-L-Phenylalanine 1-Methyl Ester
US Patent:
6384076, May 7, 2002
Filed:
Mar 22, 2001
Appl. No.:
09/787994
Inventors:
Carl V. Manion - Oklahoma City OK
Allen B. Edmundson - Oklahoma City OK
Allen B. Edmundson - Oklahoma City OK
Assignee:
Oklahoma Medical Research Foundation - Oklahoma City OK
International Classification:
A61K 3505
US Classification:
514542, 560 41
Abstract:
It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester (APM) exhibits antisickling properties. In vitro testing verified that APM significantly lowered the frequency of sickling of red blood cells from each of twelve pediatric aged patients being treated for sickle-cell anemia by exchange transfusion. Sickling was also inhibited in an âindexâ patient after oral administering of APM. These in vitro and in vivo results identify APM as a therapeutic agent for the family of sickle cell molecular diseases.
N-L-Alpha-Aspartyl-L-Phenylalanine 1-Methyl Ester And Its Derivatives For Appetite Enhancement
US Patent:
6326400, Dec 4, 2001
Filed:
Aug 25, 2000
Appl. No.:
9/648357
Inventors:
Allen B. Edmundson - Edmond OK
Carl V. Manion - Oklahoma City OK
Carl V. Manion - Oklahoma City OK
International Classification:
A61K 3124
US Classification:
514538
Abstract:
N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester and/or its derivatives has been found have appetite-stimulating effects in vertebrate animals. Preferably, it is administered by oral ingestion of either food, beverage, or food supplement.
Viscosity Modulating Substance And Use Thereof
US Patent:
6919374, Jul 19, 2005
Filed:
Sep 21, 2000
Appl. No.:
10/088713
Inventors:
Carl V. Manion - Oklahoma City OK, US
Assignee:
Oklahoma Medical Research Foundation - Oklahoma City OK
International Classification:
A61K031/235, A61K031/245, A61K038/05, A61P007/02, A61P007/06
US Classification:
514533, 514 2, 514 19, 514534, 514538, 514542, 514814, 514815, 514822, 514825
Abstract:
It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester (APM) lowers whole blood viscosity in patient, including those suffering from sickle cell disease and plasma cell dyscrasias. Upon in vivo APM treatment patients experienced a significant lowering of whole blood viscosity. In vitro addition of APM to patients samples having elevated whole blood viscosity resulted in reduced viscosity over time. These in vivo and in vivo results identify APM as a therapeutic agent for molecular diseases which lead to elevated whole blood viscosity. A method by which APM treatment can be monitored is also disclosed.
Analgesic Use Of N-L-.Alpha.-Aspartyl-L-Phenylalanine 1-Methyl Ester Derivatives
US Patent:
5998473, Dec 7, 1999
Filed:
Dec 22, 1997
Appl. No.:
8/983027
Inventors:
Allen B. Edmundson - Oklahoma City OK
Carl V. Manion - Oklahoma City OK
Carl V. Manion - Oklahoma City OK
Assignee:
Oklahoma Medical Research Foundation - Oklahoma City OK
International Classification:
A61K 3124
US Classification:
514538
Abstract:
The present invention is directed to compositions comprising N-L-alpha-aspartyl-L-phenylalanine and esters thereof as well as to method of treating pain which comprises administering such a composition to a patient in need thereof.
Analgesic Use Of N-L-.Alpha.-Aspartyl-L-Phenylalanine 1-Methyl Ester
US Patent:
5654334, Aug 5, 1997
Filed:
Jan 25, 1996
Appl. No.:
8/590409
Inventors:
Allen B. Edmundson - Oklahoma City OK
Carl V. Manion - Oklahoma City OK
Carl V. Manion - Oklahoma City OK
Assignee:
Oklahoma Medical Research Foundation - Oklahoma City OK
International Classification:
A61K 3124
US Classification:
514538
Abstract:
N-L-. alpha. -aspartyl-L-phenylalanine 1-methyl ester and/or its derivatives has been found to have analgesic pain relieving properties. It has been found to be especially effective in relieving pain associated with osteoarthritis and multiple sclerosis. It can be administered by itself or in combination with other analgesics. When given in combination with other analgesics, N-L-. alpha. -aspartyl-L-phenylalanine 1-methyl ester and/or its derivatives helps to alleviate the detrimental side effects of other analgesic medications by lowering the dosage requirements for pain relief.
N-L-Alpha-Aspartyl-L-Phenylalanine 1-Methyl Ester And Its Derivatives For Appetite Enhancement
US Patent:
6156795, Dec 5, 2000
Filed:
Aug 27, 1999
Appl. No.:
9/385221
Inventors:
Allen B. Edmundson - Oklahoma City OK
Carl V. Manion - Oklahoma City OK
Carl V. Manion - Oklahoma City OK
Assignee:
Oklahoma Medical Research Foundation - Oklahoma City OK
International Classification:
A61K 3124
US Classification:
514538
Abstract:
N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester and/or its derivatives has been found have appetite-stimulating effects in vertebrate animals. Preferably, it is administered by oral ingestion of either food, beverage, or food supplement.