CARL THEODORE BRIGHTON
Medical Practice in Frazer, PA

4430999, Feb 14, 1984

Nov 10, 1981

6/320309

Carl T. Brighton - Malvern PA
Jonathan Black - King of Prussia PA
Joyce K. Eyerly - White Bear Lake MN

Trustees of the University of Pennsylvania
Zimmer, Inc.

A61N 118

128419F

A cathode assembly for use in conjunction with an internal fracture fixation device for the purpose of stimulating osteogenesis (bone growth) within a fracture site. The assembly is comprised of a carrier made from an implantable non-conductive material containing a cathode with a conductive cable leading from the cathode to the patient's electrical bone growth stimulating apparatus. The carrier is mountable on the fixation device for maintenance at the desired location. In a preferred embodiment, a sleeve carrier contains a plurality of ports which allow the current generated by the stimulating device to flow through the cable to the cathode where it is evenly distributed through the ports to the bone tissue. The sleeve can be slipped onto a fracture fixation device, such as a compression hip screw, and is located on the device such that the sleeve containing the cathode lies across the fracture site.

8065015, Nov 22, 2011

Jul 3, 2008

12/167283

Carl T. Brighton - Malvern PA, US
Solomon R. Pollack - North Wales PA, US

The Trustees of the University of Pennsylvania - Philadelphia PA

C12N 13/00

607 50, 4351738

Methods and devices for the regulation of gene expression by cells via the application of fields generated by specific and selective electric and electromagnetic signals so as to target diseased or injured tissue for treatment. By gene expression is meant the up regulation or down regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased tissue that include providing specific and selective electric and electromagnetic signals and exposing tissue to the fields generated by the signals so as to regulate gene expression. In particular, methods and devices are provided for the targeted treatment of bone defects, osteoarthritis, osteoporosis, cancer, and other disease states.

7354748, Apr 8, 2008

May 9, 2005

11/125047

Carl T. Brighton - Malvern PA, US

The Trustees of The University of Pennsylvania - Philadelphia PA

C12N 13/00

4351738, 607 50

A method for applying therapeutic electrical signals and/or electromagnetic fields to a patient's knee for the treatment of osteoarthritis and other diseases, defects and injuries. The device that is used is operable in several modes to deliver signals to the patients knee so as to cause an electric and/or electromagnetic field to be generated that selectively up-regulates gene expression of Aggrecan and Type II Collagen while simultaneously selectively down-regulating the gene expression of metalloproteases. The device includes a signal generator that generates compound electric signals including a 60 kHz sine wave having a peak to peak voltage of approximately 4. 6 V to 7. 6 V and a 100% duty cycle signal that is generated for approximately 30 minutes and a 50% duty cycle signal that is generated for approximately 1 hour after the 100% duty cycle signal. These compound electric signals are communicated to electrodes or coils in the proximity of a patient's knee for the generation of a specific and selective electromagnetic field that treats the diseased tissue.

4442846, Apr 17, 1984

Nov 10, 1981

6/320110

Carl T. Brighton - Malvern PA
Jonathan Black - King of Prussia PA

University of Pennsylvania - Philadelphia PA

A61N 104

128784

Disclosed is an improved bone-piercing cathode for providing electrical stimulation of osteogenesis at a plurality of locations. A conventional bone-piercing cathode is modified by adding a number of "ports" extending through the insulative covering to expose the cathode permitting a flow of osteogenesis stimulating current therethrough. In a preferred embodiment, seven ports are spaced three on one side and four on the other of a conventional bone-piercing cathode which is inserted into the fracture site. Sufficient current is supplied to the cathode in order to insure that each port as well as the insulation-bare wire junction can supply 20 microamperes of osteogenesis stimulating current into the body tissues. This permits bone growth stimulation adjacent a plurality of sites on the cathode.

8313908, Nov 20, 2012

Nov 23, 2011

13/303497

Carl T. Brighton - Malvern PA, US

The Trustees Of The University Of Pennsylvania - Philadelphia PA

C12Q 1/68, C12N 13/00

435 61, 4351738, 607 50

Methods and devices are described for the regulation of BMP 2 and 4, TGF-beta 1, 2, and 3, FGF-2, osteocalcin, and alkaline phosphatase mRNA in stem cells via capacitive coupling or inductive coupling of specific and selective electric and/or electromagnetic fields to the bone cells or other tissues containing the stem cells, where the specific and selective fields are generated by application of specific and selective signals to field generating devices disposed with respect to the stem cells so as to facilitate the treatment of diseased or injured bone and other tissues. The resulting methods and devices are useful for the targeted treatment of osteoporosis, osteopenia, osteonecrosis, fresh bone fractures, fractures at risk, nonunion, bone defects, spine fusion, and/or other conditions in which BMP 2 and 4, TGF-beta 1, 2, and 3, FGF-2, osteocalcin, and alkaline phosphatase mRNA and/or protein deficiencies in stem cells has been implicated.

7374916, May 20, 2008

Sep 26, 2002

10/255241

Carl T. Brighton - Malvern PA, US

The Trustees Of The University of Pennsylvania - Philadelphia PA

C12N 13/00

4351738, 607 50

Methods and devices for the regulation of aggrecan gene expression in cartilage cells via the application of fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up regulation or down regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate fields optimized for aggrecan gene expression and exposing cartilage tissue to the fields generated by specific and selective signals so as to regulate aggrecan gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, and cartilage defects.

2009001, Jan 15, 2009

Aug 2, 2007

11/832790

Carl T. Brighton - Malvern PA, US

GENESTIM, LLC - Short Hills NJ

A61N 1/05

607 50

Methods and devices for the regulation of gene expression in tissue by applying an electric and/or electromagnetic field generated by specific and selective signals so as to treat diseases, conditions, and/or tissue. Gene expression is the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are described for the regulation of Vascular Endothelial Growth Factor (VEGF) protein gene expression in endothelial cells of various targeted tissues via the capacitive coupling or inductive coupling (e.g., by electrodes or one or more coils or other field generating devices disposed with respect to the targeted cells) of specific and selective signals to the cells of these tissues, where the resultant electric and/or electromagnetic fields treat diseased or injured tissues. The resulting methods and devices are useful for the targeted treatment of peripheral vascular disease, cardiovascular disease, macular degeneration, wound healing, tendon and ligament healing, in preventing tumor growth or spread, and other conditions in which VEGF protein may be implicated.

7429471, Sep 30, 2008

Jun 13, 2003

10/461188

Carl T. Brighton - Malvern PA, US

The Trustees of the University of Pennsylvania - Philadelphia PA

C12N 13/00

4351738, 607 50

Methods and devices for the regulation of matrix metalloproteinase gene expression in cartilage cells via the application of fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate fields optimized for reduction of matrix metalloproteinase gene expression and exposing cartilage tissue to the fields generated by specific and selective signals so as to regulate matrix metalloproteinase gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, cartilage defects, and tumor metastasis.

6919205, Jul 19, 2005

Oct 9, 2002

10/267708

Carl T. Brighton - Malvern PA, US

The Trustees of the University of Pennsylvania - Philadelphia PA

C12N005/08

435375, 435377, 4351738, 607 65

Methods and devices for the regulation of type II collagen gene expression in cartilage cells via the application of specific and selective fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up regulation or down regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate specific and selective fields optimized for type II collagen gene expression and exposing cartilage tissue to the specific and selective fields generated by specific and selective signals so as to regulate type II collagen gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, and cartilage defects.

4467808, Aug 28, 1984

Sep 17, 1982

6/419431

Carl T. Brighton - Malvern PA
Solomon R. Pollack - Dresher PA

Biolectron, Inc. - Hackensack NJ

A61N 106

128419F

Osteoporosis in a living body prevented and/or treated by applying electrodes non-invasively to a body and supplying to the electrodes an AC signal of about 5-15 volts peak-to-peak at a frequency of about 20-100 KHz to cause a treatment current to flow in a body region affected or likely to be affected by osteoporosis.