CARL T. WITTWER, MD
Medical Practice at Medical Dr, Salt Lake City, UT
License number
Utah 173346-1205
Category
Medical Practice
Type
Anatomic Pathology & Clinical Pathology
Address
Address
50 N Medical Dr, Salt Lake City, UT 84132
Phone
(801) 581-2507
(801) 213-3800
(801) 213-3800
Personal information
See more information about CARL T. WITTWER at radaris.comName
Address
Phone
3479 S Crestwood Dr, Salt Lake City, UT 84109
3034 Kennedy Dr, Salt Lake City, UT 84108
310 S 800 E #35, Salt Lake City, UT 84102
3479 Crestwood Dr, Salt Lake City, UT 84109
2568 4700 S, Salt Lake City, UT 84118
Professional information
Dr. Carl T Wittwer, Salt Lake City UT - MD (Doctor of Medicine)
Specialties:
Anatomic & Clinical Pathology
Address:
50 N Medical Dr, Salt Lake City 84132
(801) 581-2507 (Phone)
ARUP Laboratories
500 Chipeta Way, Salt Lake City 84108
(801) 583-2787 (Phone)
(801) 581-2507 (Phone)
ARUP Laboratories
500 Chipeta Way, Salt Lake City 84108
(801) 583-2787 (Phone)
Certifications:
Anatomic & Clinical Pathology, 1988
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
50 N Medical Dr, Salt Lake City 84132
ARUP Laboratories
500 Chipeta Way, Salt Lake City 84108
University of Utah Health Care
50 North Medical Dr, Salt Lake City 84132
ARUP Laboratories
500 Chipeta Way, Salt Lake City 84108
University of Utah Health Care
50 North Medical Dr, Salt Lake City 84132
Education:
Medical School
University Of Michigan Medical School
Graduated: 1984
University Of Utah
Graduated: 1988
University Of Michigan Medical School
Graduated: 1984
University Of Utah
Graduated: 1988
Method For Quantification Of An Analyte
US Patent:
6503720, Jan 7, 2003
Filed:
Feb 20, 2001
Appl. No.:
09/789170
Inventors:
Carl T. Wittwer - Salt Lake City UT
Martin Gutekunst - Eberfind, DE
Sabine Lohmann - Iffeldorf, DE
Martin Gutekunst - Eberfind, DE
Sabine Lohmann - Iffeldorf, DE
Assignee:
Roche Diagnostics GmbH
University of Utah Research Foundation - Salt Lake City UT
University of Utah Research Foundation - Salt Lake City UT
International Classification:
C12Q 168
US Classification:
435 6, 435 912, 435 39, 536 243, 536 2532
Abstract:
Methods are provided for quantifying the concentration of a nucleic acid in a nucleic acid sample. The methods include contacting the nucleic acid sample with an amplifying agent, amplifying at least one predetermined locus of the nucleic acid by subjecting the sample to a number of amplification, generating an amplification curve or array, calculating the first, second or n th order derivative of the amplification curve or array, determining a maximum, minimum, or zero value of the derivative, and using the maximum, minimum, or zero value to calculate the initial concentration of the nucleic acid in the nucleic acid sample.
Homogeneous Multiplex Hybridization Analysis By Color And Tm
US Patent:
6472156, Oct 29, 2002
Filed:
Aug 30, 2000
Appl. No.:
09/651374
Inventors:
Carl T. Wittwer - Salt Lake City UT
Mark G. Herrmann - Salt Lake City UT
Mark G. Herrmann - Salt Lake City UT
Assignee:
The University of Utah - Salt Lake City UT
International Classification:
C12Q 168
US Classification:
435 6, 435 912, 436 94, 536 2532
Abstract:
The invention provides methods and devices for analyzing sequence variations in nucleic acid samples comprising multiple loci, each having two, three or more possible allelic sequences. The method involves combining at least a first and second pair of oligonucleotide probes with the nucleic acid sample. The first pair of probes is capable of hybridizing in proximity to each other within a segment of the nucleic acid sample comprising the first locus and the second pair is capable of hybridizing in proximity to each other within a segment of the nucleic acid sample comprising the second locus. The first member of each probe pair comprises a FRET donor and the second member comprises a FRET acceptor, the FRET acceptor of the first probe pair member having a different emission spectrum from the FRET acceptor of the second probe pair. Upon hybridization, the proximity of the first and second member of each probe pair is sufficient to allow fluorescence resonance energy transfer between the FRET donor and the FRET acceptor.
Dna Amplification Using Electrolyte Conductance Heating And Temperature Monitoring
US Patent:
2002015, Oct 17, 2002
Filed:
Aug 12, 1999
Appl. No.:
09/373041
Inventors:
CARL T. WITTWER - SALT LAKE CITY UT, US
MARK G. HERRMANN - CLINTON UT, US
DAVID M. HEAP - BOUNTIFUL UT, US
MARK G. HERRMANN - CLINTON UT, US
DAVID M. HEAP - BOUNTIFUL UT, US
International Classification:
C12M001/40
US Classification:
435/286100, 435/287200, 435/303100, 435/091200, 392/323000, 204/601000
Abstract:
A system for thermal cycling a sample utilizing electrolyte conductance heating. An electric current is passed through the sample to increase its temperature due to resistance heating. As the sample acquires more thermal energy its viscosity changes, which causes a change in resistance. Because of this characteristic, temperature of the sample can be measured as a function of resistance and temperature can be controlled using resistance of the solution as feedback to a circuit which controls the heating of the sample by electrical conductance.
Multiplex Genotyping Using Fluorescent Hybridization Probes
US Patent:
6140054, Oct 31, 2000
Filed:
Sep 30, 1998
Appl. No.:
9/164023
Inventors:
Carl T. Wittwer - Salt Lake City UT
Philip S. Bernard - Salt Lake City UT
Philip S. Bernard - Salt Lake City UT
Assignee:
University of Utah Research Foundation - Salt Lake City UT
International Classification:
C12Q 168
US Classification:
435 6
Abstract:
The present invention is directed to a mutation detection kit and method of analyzing multiple loci of one or more nucleic acid sequences for the presence of mutations or polymorphisms. More particularly, the present invention relates to the use of the polymerase chain reaction (PCR) and fluorescently labeled oligonucleotide hybridization probes to identify mutations and polymorphisms based on melting curve analysis of the hybridization probes.
Amplicon Melting Analysis With Saturation Dyes
US Patent:
2012030, Nov 29, 2012
Filed:
Nov 17, 2011
Appl. No.:
13/299040
Inventors:
Carl T. Wittwer - Salt Lake City UT, US
Gudrun Reed - Salt Lake City UT, US
Virginie Dujols - Sandy UT, US
Luming Zhou - Salt Lake City UT, US
Gudrun Reed - Salt Lake City UT, US
Virginie Dujols - Sandy UT, US
Luming Zhou - Salt Lake City UT, US
International Classification:
G01N 21/64
US Classification:
435 611, 435 612, 422 8208
Abstract:
Methods are provided for nucleic acid analysis wherein a target nucleic acid that is at least partially double stranded is mixed with a dsDNA binding dye having a percent saturation of at least 50% to form a mixture. In one embodiment, the nucleic acid is amplified in the presence of the dsDNA binding dye, and in another embodiment a melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye as the mixture is heated. Dyes for use in nucleic acid analysis and methods for making dyes are also provided.
Method For Rapid Thermal Cycling Of Biological Samples
US Patent:
7238321, Jul 3, 2007
Filed:
Jul 13, 2004
Appl. No.:
10/891161
Inventors:
Carl T. Wittwer - Salt Lake City UT, US
David R. Hillyard - Salt Lake City UT, US
David R. Hillyard - Salt Lake City UT, US
Assignee:
University of Utah Research Foundation - Salt Lake City UT
International Classification:
G01N 1/00, G01N 15/00, B10J 19/18, C12P 19/34
US Classification:
422 50, 422 681, 422134, 435 912
Abstract:
A thermal cycling method and device is disclosed. The device comprises a sample chamber whose temperature can be rapidly and accurately modulated over a range of temperatures needed to carry out a number of biological procedures, such a DNA polymerase chain reaction. Biological samples are placed in glass micro capillary tubes and then located inside the sample chamber. A programmable controller regulates the temperature of the sample inside the sample chamber. Once a heating cycle is completed, the controller opens a door to the chamber for venting hot air out and cool ambient air is moved in. Temperature versus time profiles corresponding to optimum denaturation, annealing and elongation temperatures for amplification of DNA are achieved by the present invention.
Amplicon Melting Analysis With Saturation Dyes
US Patent:
7803551, Sep 28, 2010
Filed:
Aug 11, 2009
Appl. No.:
12/500860
Inventors:
Carl T. Wittwer - Salt Lake City UT, US
Virginie Dujols - Sandy UT, US
Virginie Dujols - Sandy UT, US
Assignee:
University of Utah Research Foundation - Salt Lake City UT
Idaho Technology, Inc. - Salt Lake City UT
Idaho Technology, Inc. - Salt Lake City UT
International Classification:
C12Q 1/68, C12P 19/34, C07H 21/04
US Classification:
435 6, 435 912, 536 2431, 536 24
Abstract:
Methods are provided for nucleic acid analysis wherein a target nucleic acid that is at least partially double stranded is mixed with a dsDNA binding dye having a percent saturation of at least 50% to form a mixture. In one embodiment, the nucleic acid is amplified in the presence of the dsDNA binding dye, and in another embodiment a melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye as the mixture is heated. Dyes for use in nucleic acid analysis and methods for making dyes are also provided.
Multi-Test Analysis Of Real-Time Nucleic Acid Amplification
US Patent:
2003016, Sep 4, 2003
Filed:
Feb 12, 2002
Appl. No.:
10/074178
Inventors:
David Eyre - Salt Lake City UT, US
Carl Wittwer - Salt Lake City UT, US
Carl Wittwer - Salt Lake City UT, US
International Classification:
C12Q001/68, G06F019/00, G01N033/48, G01N033/50, C12P019/34
US Classification:
435/006000, 435/091200, 702/020000
Abstract:
A method and device are described for analyzing a sample for the presence of a nucleic acid wherein the sample is amplified, illustratively using PCR, in the presence of a fluorescent probe capable of providing a signal related to the quantity of nucleic acid present. A nucleic acid sample is amplified in the presence of the fluorescent entity, and the fluorescence intensity is measured at each of a plurality of amplification cycles. Scores are obtained from various tests performed on the fluorescence data, and the scores are used to determine whether the nucleic acid is present in the sample.
Methods And Compositions Related To Continuous Flow Thermal Gradient Pcr
US Patent:
2013006, Mar 14, 2013
Filed:
Aug 8, 2012
Appl. No.:
13/569701
Inventors:
Bruce K. Gale - Taylorsville UT, US
Niel Davenport Crews - Ruston LA, US
Carl Thomas Wittwer - Salt Lake City UT, US
Niel Davenport Crews - Ruston LA, US
Carl Thomas Wittwer - Salt Lake City UT, US
International Classification:
C12P 19/34, B32B 38/04, B32B 38/14, G01N 21/64, B32B 37/14
US Classification:
435 612, 435 912, 156277, 156256
Abstract:
Disclosed are compositions and a method for amplification and detection of nucleic acid sequences based on continuous flow thermal gradient PCR.