Inventors:
P. Spencer Kinsey - Sandy Hook CT, US
Carl R. Sahi - Coventry CT, US
Benoit Adamo - Mount Kisco NY, US
John M. Polidoro - Coventry CT, US
Scott McLean - Waterbury CT, US
Dennis Overfield - Fairfield CT, US
Kelly S. Kraft - Poughquag NY, US
Karla Somerville - Corona CA, US
Assignee:
MannKind Corporation - Valencia CA
International Classification:
A61K 47/22, A61M 15/00
Abstract:
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.