Inventors:
Richard C. Duke - Denver CO, US
Donald Bellgrau - Highlands Ranch CO, US
Alex Franzusoff - Denver CO, US
Cara C. Wilson - Golden CO, US
Assignee:
GlobeImmune, Inc. - Louisville CO
The Regents of the University of Colorado, a body corporate - Denver CO
International Classification:
A61K 9/00, A61K 45/00, C12N 1/00, C12N 1/16
US Classification:
4241841, 424 9351, 4242781, 4352551
Abstract:
Disclosed is a vaccine that includes a dendritic cell loaded with a yeast vehicle and antigen. Also disclosed are methods of making the vaccine and using the vaccine to elicit cellular and humoral immune responses in a mammal. Additionally, a method to elicit an immune response by administration of a yeast vehicle and an antigen that is not complexed to the yeast vehicle is disclosed.