CAMILLO RICORDI, MD
Osteopathic Medicine in Miami, FL

6281341, Aug 28, 2001

Jun 17, 1997

8/877682

Marcos Mares-Guia - Miami Beach FL
Camillo Ricordi - Miami Beach FL

Biomm, Inc. & University of Miami - Miami FL

C08B 3704, A01N 6300, A61K 914

536 3

Disclosed and claimed are: a composition including at least one glycosaminoglycan, e. g. , CIS, and at least one alginate, e. g. , sodium alginate, wherein: the at least one glycosaminoglycan and/or the algninate are cross-linked or polymerized, e. g. , the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt; or the at least one glycosaminoglycan and the alginate are covalently bound, e. g. , by means of a coupling reaction involving a linker molecule such as DVS; or the at least one glycosaminoglycan and/or the algninate are cross-linked or polymerized, e. g. , the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt, and the at least one glycosaminoglycan and the alginate are covalently bound, e. g. , by means of a coupling reaction involving a linker molecule such as DVS, and the covalent binding can have been performed prior to cross-linking or polymerizing or vice versa; and, gels comprising the composition; mixtures of such gels or of at least one such gel and at least one such composition; and, methods for making and using such compositions and gels, including products therefrom such as "paints", sprays, matrices, beads, microcapsules.

2005014, Jun 30, 2005

Feb 15, 2005

11/057994

Ramon Poo - Miami FL, US
Camillo Ricordi - Miami FL, US

Biorep Technologies, Inc. - Miami FL
University of Miami - Miami FL

A01N001/00, A01N001/02

435001100

A method for storing organs, cells, and tissues, includes the steps of providing a gas impermeable container; providing a preservation solution containing dissolved oxygen; placing the preservation solution into the container with the organ, cell or tissue; and hermetically closing said container. A system for storing organs, cells, and tissue includes a gas impermeable organ container for the organs, cells and tissue. A hermetically sealable solution container is provided for storing a preservation solution. The preservation solution contains dissolved oxygen. A dispensing structure is provided for placing the solution into the organ container. The preservation solution can include an oxygen-carrier solution and UW solution. The oxygen-carrier solution can be perfluorocarbon.

2004020, Oct 14, 2004

Apr 10, 2003

10/410954

Ramon Poo - Miami FL, US
Camillo Ricordi - Miami FL, US

A01N001/00, A01N001/02

435/001100

A method for storing organs, cells, and tissues, includes the steps of providing a gas impermeable container; providing a preservation solution containing dissolved oxygen; placing the preservation solution into the container with the organ, cell or tissue; and hermetically closing said container. A system for storing organs, cells, and tissue includes a gas impermeable organ container for the organs, cells and tissue. A hermetically sealable solution container is provided for storing a preservation solution. The preservation solution contains dissolved oxygen. A dispensing structure is provided for placing the solution into the organ container. The preservation solution can include an oxygen-carrier solution and UW solution. The oxygen-carrier solution can be perfluorocarbon.

2010014, Jun 10, 2010

Dec 8, 2009

12/633270

Cherie Stabler - Coral Gables FL, US
Kristina Finn - Gainesville FL, US
Camillo Ricordi - Miami FL, US
Hernan R. Rengifo - Deerfield Beach FL, US

A61K 9/48, A61K 35/00, A61K 31/7088

424463, 424451, 424 931, 514 44 R

A biocompatible capsule comprising a biological material encapsulated by a covalently stabilized coating and a method of making the same are disclosed. The biological material can be a material selected from the group consisting of cells, such as islets of Langerhans, pharmaceuticals, and biological agents. The coating can be formed by reacting an alginate-[polyalkylene glycol (PAG)-X], and a multi-functional PAG-X, to form covalent bonds, wherein n is an integer greater than 0, a first one of Xand Xis N, and a second one of Xand Xis selected from the group consisting of:wherein R=CH, CHCH, CH(CH),

5772994, Jun 30, 1998

Jun 5, 1995

8/463908

Suzanne T. Ildstad - Pittsburgh PA
Richard L. Simmons - Pittsburgh PA
Camillo Ricordi - Miami Beach FL
Sherry M. Wren - Pittsburgh PA
Christina Kaufman - Munhall PA

The University of Pittsburgh - Pittsburgh PA

A01N 6300, C12N 1500

424 937

The present invention relates to mammalian hematopoietic facilitatory cells (FC). In particular, it relates to the isolation, characterization and uses of the FC. The FC of the present invention can be distinguished from all other known bone marrow cells by their morphology, cell surface phenotype and in vivo function. It has now been established that purified hematopoietic stem cells alone or bone marrow cells depleted of FC do not readily engraft in a recipient. When co-administered with other bone marrow cells, especially the hematopoietic stem cells into a recipient, the FC enhance their engraftment, without apparent adverse biologic activities. In fact, the ability of the FC to enhance the engraftment of bone marrow cells in esablishing lymphohematopoietic chimerism without producing graft versus host disease also induces donor-specific tolerance to permit the permanent acceptance of donor's cells, tissues and organs. Therefore, FC may have a wide range of applications, including, but not limited to, hematopoietic reconstitution by bone marrow transplantation for the treatment of cancers, anemias, autoimmunity, immunodeficiency, viral infections and metabolic disorders as well as facilitation of solid organ, tissue and cellular transplantation.

2010000, Jan 7, 2010

Jun 8, 2007

12/308234

Hirohito Ichii - North Bay Village FL, US
Camillo Ricordi - Miami FL, US

University of Miami - Miami FL

G01N 1/30, C12Q 1/68

435 6, 435 405

A method of assessing cellular composition and fractional viability that can be predictive of post-transplant cell potency and transplantation outcome, comprises identifying cellular composition and assessing cellular viability. This has particular importance in the field of tissue and cell transplantation, cell therapy and regenerative medicine, providing a method for tissue and cell characterization, viability and potency testing, that could be useful for the definition of product release criteria for research and clinical applications.

7910359, Mar 22, 2011

Jul 20, 2005

11/185011

Camillo Ricordi - Miami FL, US

University of Miami - Miami FL

A61M 5/14

4352972, 6048911, 435177, 4352841, 4352864, 424422

A device for receiving implanted biological material includes a porous outer wall defining an inner space, a fluid manifold assembly for selectively infusing at least one of immunosuppressive and growth factor media to said space, and a pump structure operatively coupled to the manifold assembly. The device may comprise an additional plunger body for being disposed in said space and so as to define a peripheral gap between the plunger and the perforated wall of the device.

2010020, Aug 12, 2010

Feb 1, 2008

12/524918

Nicholas Bodor - Bal Harbour FL, US
Peter Buchwald - Weston FL, US
Christopher A. Fraker - Hollywood FL, US
Jeffrey Hubbell - Morges, CH
Luca Inverardi - Miami Beach FL, US
Norma Sue Kenyon - Miami FL, US
Paul Latta - Miami FL, US
Antonello Pileggi - Aventura FL, US
Cheryl Stabler Anderson - Coral Gables FL, US
Fabio Grassi - Bellinzona, CH
Camillo Ricordi - Miami FL, US

A61M 5/14

6048911

A device () for receiving implanted biological material includes a mechanoprotective surface () defining an adjacent space, an assembly () for locally delivering media to said space, and a pump or slow/sustained release reservoir structure () operatively coupled to the assembly. The device may comprise an additional plunger body for being disposed in said space. The implanted biological material may be encapsulated or non-encapsulated.

2007029, Dec 20, 2007

Dec 13, 2006

11/638244

Norma Kenyon - Miami FL, US
Camillo Ricordi - Miami FL, US
David Thomas - Wellesley MA, US
Linda Burkly - West Newton MA, US

A61K 39/395, A61P 43/00

424172100

Methods and compositions for inhibiting rejection of insulin-producing tissue in a graft recipient, as well as methods and compositions for prolonging graft survival or function; for reversing graft rejection or restoring function of an impaired graft; and, for inducing immunological tolerance to grafted, insulin-producing tissue. The present methods and compositions are suitable for treatment or prophylaxis of defects in metabolic control of blood glucose homeostasis, including defects manifested as diabetes mellitus (DM).

8263389, Sep 11, 2012

Jun 30, 2010

12/827703

Ramon E. Poo - Miami FL, US
Camillo Ricordi - Miami FL, US
Felipe Echeverri - Miami FL, US
Over Cabrera - Deerfield Beach FL, US
Per-Olof Berggren - Miami FL, US

Biorep Technologies, Inc. - Miami FL
University of Miami - Miami FL

C12M 3/00, C12M 1/36

4352865, 4352873, 4352931, 137597

A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided so that the flow of liquids from source containers to the sample containers can be varied and controlled. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A programmable controller can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature.