Inventors:
Cameron J Turtle - Seattle WA, US
Stanley R. Riddell - Sammamish WA, US
Assignee:
Fred Hutchinson Cancer Research Center - Seattle WA
International Classification:
A61K 51/00, C12N 5/071, C12N 5/0783, A61K 35/12, A61K 39/395, G01N 33/566, A61P 35/00, A61P 31/00, A61P 29/00, A61P 37/00, A61P 37/06
US Classification:
424 149, 435325, 424 9371, 4241581, 4241451, 435375, 435 724, 4241331
Abstract:
This invention provides, among other things, methods for the identification and isolation of viable putative long-lived antigen-specific memory CD8 T cell subsets (CMhi and EMhi) with high surface expression of CD161 and/or IL-18Rα and the capacity to rapidly efflux the fluorescent dye Rh123.