Inventors:
Yang V. Li - Athens OH, US
Caleb O. Molokwu - Dayton OH, US
Assignee:
OHIO UNIVERSITY - Athens OH
International Classification:
A61K 31/663, A61K 31/565, A61K 31/566, A61K 31/65, A61K 31/47, A61K 31/44, A61P 19/10, A61P 19/08
US Classification:
514108, 514171, 514154, 514311, 514357
Abstract:
Disclosed herein are methods and compositions for the treatment and prevention of bone loss. The methods comprise providing a therapeutically effective amount of at least one chelating agent to a subject. The methods further comprise providing a therapeutically effective amount of estrogen or at least one estrogen analogue to a subject. Compositions disclosed herein for the treatment and prevention of bone loss comprise a chelator and estrogen or at least one estrogen analogue. The compositions further comprise at least one of a bisphosphonate, a selective estrogen receptor modulator, or a hormone.