BRYAN T ORONSKY
Physician at Matadero Crk Ln, Los Altos, CA

2007022, Sep 27, 2007

Jul 18, 2006

11/488945

John Sliwa - Los Altos CA, US
Carol Tosaya - Los Altos CA, US
Bryan Oronsky - Los Altos CA, US

A61K 48/00, A61K 9/00

424093200, 424400000

A gel-like material is provided, the gel-like material having an on-demand state-change capability, whether the on-demand change is to an initial state, a final state or both, at least some of the gel present or delivered undergoing the change. Alternatively, the gel-like material may have a spatially and/or temporally selective state-change, whether on-demand change is to an initial state, a final state or both, at least some of the gel present or delivered undergoing the change. Or, the gel-like material may selectively change state due to gel contacting diseased tissue having a natural thermal or compositional contrast or artificially induced thermal or compositional contrast capable of causing state-change via a state-change parameter, independent of an on-demand nature or a spatial/temporal selective nature.

2009009, Apr 9, 2009

Oct 5, 2007

11/973052

John W. Sliwa - Los Altos CA, US
Bryan T. Oronsky - Los Altos CA, US
Herbert L. Berman - Los Altos Hills CA, US
Neil C. Oronsky - Los Altos Hills CA, US
Carol A Tosaya - Los Altos Hills CA, US
George W. Keilman - Woodinville WA, US

A61M 5/32

604116

Many medical procedures, such as needle-sticking, could benefit from an assistive device that improves the optical contrast of externally targeted features and lumens of interest residing in and underneath the skin and/or exposed organ tissues. The inventive inexpensive device and method are useable on such externally targeted features and lumens while also protecting the practitioner and freeing up both of his/her hands, if necessary, to thereby eliminate practitioner self-sticking problems. The present device provides good optical contrast and also provides splash-protection against HIV, hepatitis and other blood-borne diseases. The inventive device method and apparatus may also include vibratory subcutaneous electrical nerve stimulation (TENS), drug-based or heating treatment capabilities for reducing pain, both perceived and real pain, associated with a device guided procedure. Finally, the pain reduction mechanisms have also been found useful for lumen dilation.

2008031, Dec 18, 2008

Jun 16, 2008

12/140080

Bryan T. ORONSKY - Los Altos Hills CA, US
Neil C. Oronsky - Los Altos Hills CA, US
Arnold L. Oronsky - Los Altos Hills CA, US

A61M 35/00, A61M 37/00

604 46, 604265, 604290

Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as “lipophilic vehicle” or “LV” and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The LV may contain a penetration enhancer, most preferably one with membrane disruptive properties. The formulation may be applied to or impregnated into a gauze, wrap, bandage, cotton-tipped stick, adhesive bandage strip, or other support wrap or medical bandage or wound cover. For example, the compositions may be are incorporated onto or into disposables such as hemorrhoid wipes, sponge, mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.

2009031, Dec 17, 2009

Apr 10, 2009

12/422156

Bryan T. Oronsky - Los Altos Hills CA, US
Neil C. Oronsky - Los Altos Hills CA, US

A61K 31/485, A61K 31/554, A61K 31/496, A61K 31/53, A61K 33/00, A61P 25/00

424722, 51421113, 51425404, 514242, 514282

Treatment regimens for mood disorders that include administration of buprenorphine, alone or in combination with additional pharmacological agents are described. Specifically, treatment regimens that alleviate racing thoughts associated with bipolar disorder, and pharmaceutical compositions and kits for use therein are described. Dosing regimens, compositions, and kits including buprenorphine for treating mania associated with opioid withdrawal are also described.

2013005, Feb 28, 2013

Aug 24, 2012

13/593737

Jan Scicinski - Saratoga CA, US
Bryan T. Oronsky - Los Altos Hills CA, US
Robert Wardle - Logan UT, US
Louis Cannizzo - Ogden UT, US
Nicholas A. Straessler - North Salt Lake UT, US

A61K 31/08, A61K 31/27, A61K 31/17, A61K 31/16, A61K 31/18, C07D 401/12, A61K 31/225, A61K 31/444, A61P 35/00, C07C 205/29, C07C 205/49, A61K 31/265, A61K 31/22

514332, 514716, 514512, 514478, 514484, 514489, 514588, 514626, 514601, 514551, 514547, 514531, 568589, 558276, 546326

The present invention provides acyclic, geminal-dinitro organic compounds, methods of synthesizing the compounds, pharmaceutical compositions, therapeutic methods, and medical kits for treating various conditions using such compounds and pharmaceutical compositions. The compounds and compositions are useful in the treatment of cancer.

2009026, Oct 29, 2009

Apr 28, 2008

12/150505

John W. Sliwa - Los Altos Hills CA, US
Bryan T. Oronsky - Los Altos CA, US
Herbert L. Berman - Palo Alto CA, US
Neil C. Oronsky - Los Altos Hills CA, US

G01N 33/00

116206

A buoyant-capable sensor system device is disclosed for use alone or on an apparatus such as a straw, stirrer, mixer, stick or utensil which detects the presence or absence of one or more substances in a beverage or liquid food such as soup comprising a sensing element(s) which is either in direct or indirect contact with the beverage or food and a buoyant sensor body to assure user-visibility of the sensing element(s).

2012023, Sep 13, 2012

Mar 14, 2012

13/420025

Bryan T. Oronsky - Los Altos Hills CA, US
Neil C. Oronsky - Los Altos Hills CA, US

ComGenRx, Inc. - Mountain View CA

A61K 31/485, A61K 31/496, A61P 25/18, A61K 31/519, A61K 31/554, A61K 33/00, A61K 31/5513

424722, 514279, 51425307, 514220, 51425941, 51421113, 51425404, 514282

Treatment regimens for mood disorders that include administration of buprenorphine, alone or in combination with additional pharmacological agents are described. Specifically, treatment regimens that alleviate racing thoughts associated with bipolar disorder, and pharmaceutical compositions and kits for use therein are described. Dosing regimens, compositions, and kits including buprenorphine for treating mania associated with opioid withdrawal are also described.

2012014, Jun 14, 2012

Dec 9, 2011

13/315888

Bryan T. Oronsky - Los Altos Hills CA, US
Susan Knox - Stanford CA, US
Jan Scicinski - Saratoga CA, US
Shoucheng Ning - Santa Clara CA, US

A61K 31/397, A61K 31/4468, A61K 31/12, A61K 31/16, A61K 31/04, A61P 35/02, A61K 31/445, A61K 31/255, A61K 31/22, A61K 31/40, A61P 35/00

51421017, 514423, 514315, 514676, 51421001, 514426, 514628, 514517, 514518, 514550, 514742, 514740

The invention provides organonitro compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat non-Hodgkin's lymphoma and certain leukemias in a patient. The compounds, compositions, kits, and methods are contemplated to provide a therapeutic benefit in treating non-Hodgkin's lymphoma, chronic lymphocytic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, and acute lymphoblastic leukemia. Exemplary organonitro compounds described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.

2007029, Dec 20, 2007

Jun 15, 2007

11/818685

John Sliwa - Los Altos CA, US
Bryan Oronsky - Los Altos CA, US

A61B 5/103

600587000

Prostate probe systems are disclosed for assessing one or both of BPH or prostate cancer. The prostate probe systems comprise either a force or pressure sensor mounted on or in a rectally insertable probe or a temperature sensor mounted on or in a rectally insertable probe, or both. Also disclosed are probe systems for evaluating a condition of a prostate gland. Finally, force or hardness mapping devices are disclosed for palpation-examination of patient anatomical tissues for abnormalities or assessing states of firmness.

2009019, Jul 30, 2009

Jan 24, 2008

12/019460

Bryan Todd Oronsky - Los Altos Hills CA, US
Neil Charles Oronsky - Los Altos Hills CA, US

A61K 31/21, A61K 33/04, A61K 31/405, A61K 31/381, A61P 25/00, A61K 31/343, A61K 31/34

424702, 514706, 514470, 514509, 514415, 514469, 514443

The formulation provides a method of treating headaches, neck, joint and inflammatory-type pain in a mammalian subject by administering to the subject a therapeutically effective amount of a nitrate-containing compound and a therapeutically effective amount of a selenium-containing compound. The formulation also provides kits and systems for practicing the subject methods.