Inventors:
Bruce T. Liang - Merion Station PA
Kenneth A. Jacobson - Silver Spring MD
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
The Trustees of the University of Pennsylvania - Philadelphi PA
International Classification:
A61K 3170
Abstract:
Compositions and methods for reducing or preventing ischemic damage of the heart are disclosed. A preferred embodiment of the invention comprises the simultaneous administration of specific A3/A1 receptor agonists, to patients suffering from ischemic damage or at risk for the same. In yet another embodiment of the invention, a binary conjugate which acts as an agonist for the A3 receptor and an antagonist at the A2 receptor, is administered to reduce or prevent ischemic damage to the heart.