Inventors:
John Gwynne - Doylestown PA, US
Philippe Vitou - Paris, FR
Bruce Randazzo - Rydal PA, US
International Classification:
A61K031/4439, A61K031/405, A61K031/155
US Classification:
514/323000, 514/419000, 514/635000
Abstract:
This invention provides methods of using a pharmacological combination of a biguanide agents, such as metformin, and one or more PTPase inhibiting agents and, optionally, one or more sulfonlylurea agents, including glyburide, glyburide, glipizide, glimepiride, chlorpropamide, tolbutamide, or tolazamide, for treatment in a mammal of Syndrome X, type II diabetes or metabolic disorders mediated by insulin resistance or hyperglycemia. Further included in this invention is a method of modulating blood glucose levels in a mammal utilizing the combination of one or more PTPase inhibiting agents and one or more sulfonlylurea agents.