BRUCE LAMONT INNIS
Medical Practice in Haverford, PA
License number
Pennsylvania MD420371
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Haverford, PA 19041
Professional information
Multivalent Dengue Virus Vaccine
US Patent:
6638514, Oct 28, 2003
Filed:
Mar 24, 2000
Appl. No.:
09/535117
Inventors:
Kenneth H. Eckels - Rockville MD
Joseph R. Putnak - Silver Spring MD
Doria R. Dubois - Wheaton MD
Bruce L. Innis - Haverford PA
Charles H. Hoke - Columbia MD
Sun Wellington - Rockville MD
Joseph R. Putnak - Silver Spring MD
Doria R. Dubois - Wheaton MD
Bruce L. Innis - Haverford PA
Charles H. Hoke - Columbia MD
Sun Wellington - Rockville MD
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
A61K 39193
US Classification:
4242181, 4242021
Abstract:
The present invention provides vaccine compositions of attenuated dengue virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against all four dengue virus serotypes by administration of attenuated dengue-1, dengue-2, dengue-3, and dengue-4 virus.
Adaptation Of Virus To Vertebrate Cells
US Patent:
6613556, Sep 2, 2003
Filed:
Mar 24, 2000
Appl. No.:
09/534724
Inventors:
Kenneth H. Eckels - Rockville MD
Joseph R. Putnak - Silver Spring MD
Bruce L. Innis - Haverford PA
Joseph R. Putnak - Silver Spring MD
Bruce L. Innis - Haverford PA
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
C12N 700
US Classification:
4352351, 435 9133, 4242041, 4242181
Abstract:
The present invention provides a method for replicating virus to high titer in cultured mammalian cells by infecting the mammalian cells with the high titer virus strain to obtain infected cells, specifically, attenuated dengue virus strains of serotype 1, 2, 3, and 4. The resulting replicated virus is suitable for use in vaccines and vaccination methods which are also provided by the invention.
Attenuated Dengue-2 Virus Vaccine
US Patent:
6511667, Jan 28, 2003
Filed:
Mar 24, 2000
Appl. No.:
09/534725
Inventors:
Kenneth H. Eckels - Rockville MD
Joseph R. Putnak - Silver Spring MD
Doria R. Dubois - Wheaton MD
Bruce L. Innis - Haverford PA
Charles H. Hoke - Columbia MD
David Vaughn - Silver Spring MD
Niranian Kanesa-thasan - Rockville MD
Joseph R. Putnak - Silver Spring MD
Doria R. Dubois - Wheaton MD
Bruce L. Innis - Haverford PA
Charles H. Hoke - Columbia MD
David Vaughn - Silver Spring MD
Niranian Kanesa-thasan - Rockville MD
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
A61K 39193
US Classification:
4242181, 435237
Abstract:
The present invention provides vaccine compositions of attenuated dengue-2 virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against dengue-2 virus by administration of attenuated dengue-2 virus.
Attenuated Dengue-4 Virus Vaccine
US Patent:
6537557, Mar 25, 2003
Filed:
Mar 24, 2000
Appl. No.:
09/534726
Inventors:
Kenneth H. Eckels - Rockville MD
Joseph R. Putnak - Silver Spring MD
Doria R. Dubois - Wheaton MD
Bruce L. Innis - Haverford PA
Charles H. Hoke - Columbia MD
David Vaughn - Silver Spring MD
Joseph R. Putnak - Silver Spring MD
Doria R. Dubois - Wheaton MD
Bruce L. Innis - Haverford PA
Charles H. Hoke - Columbia MD
David Vaughn - Silver Spring MD
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
A61K 39193
US Classification:
4242181, 435236
Abstract:
The present invention provides vaccine compositions of attenuated dengue-4 virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against dengue-4 virus by administration of attenuated dengue-4 virus.
Multivalent Dengue Virus Vaccine
US Patent:
7217418, May 15, 2007
Filed:
Jul 24, 2003
Appl. No.:
10/626315
Inventors:
Kenneth H. Eckels - Rockville MD, US
Joseph B. Putnak - Silver Spring MD, US
Doria R. Dubois - Wheaton MD, US
Bruce L. Innis - Haverford PA, US
Charles H. Hoke - Columbia MD, US
Wellington Sun - Rockville MD, US
Niranjan Kanesa-Thasan - Rockville MD, US
Joseph B. Putnak - Silver Spring MD, US
Doria R. Dubois - Wheaton MD, US
Bruce L. Innis - Haverford PA, US
Charles H. Hoke - Columbia MD, US
Wellington Sun - Rockville MD, US
Niranjan Kanesa-Thasan - Rockville MD, US
Assignee:
United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
A61K 39/295
US Classification:
4242021, 4242181
Abstract:
The present invention provides vaccine compositions of attenuated dengue virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against all four dengue virus serotypes by administration of attenuated dengue-1, dengue-2, dengue-3, and dengue-4 virus.