Inventors:
Bruce J. Dezube - Newton MA, US
Lilli M. Petruzzelli - Lexington MA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A61K 31/519, A61P 35/00
Abstract:
Disclosed are methods for the treatment of patients with diseases, disorders or conditions responsive to the inhibition of NAE (Nedd8-activating enzyme), e.g., cancer. The methods comprise administering a clinically effective amount of the NAE-inhibitor ((1S,2S,4R)-4-(4-((1S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate (MLN4924) according to an intermittent dosing regimen in which there is a rest period of at least two days between each administration.