DR. BRUCE DALE WEINTRAUB, M.D.
Osteopathic Medicine at Medical Center Dr, Rockville, MD
License number
Maryland D0034879
Category
Osteopathic Medicine
Type
Endocrinology, Diabetes & Metabolism
Address
Address
9714 Medical Center Dr SUITE 1114, Rockville, MD 20850
Phone
(301) 838-1935
(301) 762-6287 (Fax)
(301) 762-6287 (Fax)
Personal information
See more information about BRUCE DALE WEINTRAUB at radaris.comName
Address
Phone
13540 Stonebarn Ln, North Potomac, MD 20878
22826 Howard Chapel Rd, Brookeville, MD 20833
13540 Stonebarn Ln, Gaithersburg, MD 20878
6620 Sulky Ln, Rockville, MD 20852
20 W Gude Dr, Rockville, MD 20850
Professional information
Bruce Dale Weintraub, Rockville MD
Specialties:
Internal Medicine, Endocrinology and Metabolism, Endocrinology, Diabetes & Metabolism
Work:
Chief Scientific Officer
6 Taft Ct, Rockville, MD 20850
6 Taft Ct, Rockville, MD 20850
Education:
Harvard University(1966)
Follicle Stimulating Hormone Superagonists
US Patent:
2007021, Sep 20, 2007
Filed:
Mar 18, 2005
Appl. No.:
10/593466
Inventors:
Mariusz Szkudlinski - Rockville MD, US
Bruce Weintraub - Rockville MD, US
Bruce Weintraub - Rockville MD, US
International Classification:
A61K 38/24, C07H 21/04, C07K 14/59, C12N 15/63, C12N 5/06, C12N 5/08
US Classification:
514002000, 435320100, 435325000, 435375000, 530399000, 536023510
Abstract:
This invention provides superactive analogs of FSH demonstrating enhanced bioactivity both in vitro and in vivo as compared to wild type FSH. In particular, the analogs of the invention demonstrate at least a ten fold increase in potency or at least a ten percent increase in maximal efficacy as compared to wild type protein. The analogs are particularly useful for treating subjects showing low FSH receptor expression or poor FSH receptor responsiveness, and for the treatment of any condition associated with glycoprotein hormone activity.
Biologically Active Synthetic Thyrotropin And Cloned Gene For Producing Same
US Patent:
2008010, May 8, 2008
Filed:
Oct 26, 2007
Appl. No.:
11/977791
Inventors:
Frederic Wondisford - Rockville MD, US
Bruce Weintraub - Rockville MD, US
Bruce Weintraub - Rockville MD, US
International Classification:
A61K 36/00, A61K 48/00, C07K 16/00, A61P 43/00, G01N 33/53
US Classification:
424009200, 530399000, 530412000, 435007100, 514012000
Abstract:
Substantially pure recombinant TSH has been prepared from a clone comprising complete nucleotide sequence for the expression of the TSH. Diagnostic and therapeutic applications of the synthetic TSH are described.
Biologically Active Synthetic Thyrotropin And Cloned Gene For Producing Same
US Patent:
2001005, Dec 20, 2001
Filed:
Jun 27, 2001
Appl. No.:
09/892266
Inventors:
Fredric Wondisford - Rockville MD, US
Bruce Weintraub - Rockville MD, US
Bruce Weintraub - Rockville MD, US
International Classification:
C12N015/09
US Classification:
435/069400
Abstract:
Substantially pure recombinant TSH has been prepared from a clone comprising complete nucleotide sequence for the expression of the TSH. Diagnostic and therapeutic applications of the synthetic TSH are described.
Cystine Knot Growth Factor Mutants
US Patent:
2002016, Nov 14, 2002
Filed:
Mar 20, 2001
Appl. No.:
09/813398
Inventors:
Bruce Weintraub - Rockville MD, US
Mariusz Szkudlinski - Potomac MD, US
Mariusz Szkudlinski - Potomac MD, US
International Classification:
A61K038/22, C07H021/04, C12P021/02, C12N005/06, C07K014/575
US Classification:
530/397000, 514/008000, 536/023500, 435/069400, 435/325000, 435/320100
Abstract:
Compositions and methods based on mutant Cystine Knot Growth Factors (CKGFs) comprising amino acid substitutions relative to the wild type hormone/growth factor. Mutated glycoprotein hormones, including thyroid stimulating hormone (TSH) and chorionic gonadotropin (CG) are disclosed as exemplary mutant CKGFs. Mutant TSH heterodimers and hCH heterodimers possessed modified bioactivities, including superagonist activity. Accordingly, the present invention provides methods for using mutant CKGFs, CKGF analogs, fragments, and derivatives thereof for treating or preventing diseases. Pharmaceutical and diagnostic compositions, methods of using mutant TSH heterodimers and TSH analogs with utility for treatment and prevention of metabolic and reproductive diseases are also provided.
Biologically Active Synthetic Thyrotropin And Cloned Gene For Producing Same
US Patent:
2004013, Jul 8, 2004
Filed:
Dec 16, 2003
Appl. No.:
10/737469
Inventors:
Frederic Wondisford - Rockville MD, US
Bruce Weintraub - Rockville MD, US
Bruce Weintraub - Rockville MD, US
International Classification:
C07H021/04, C07K014/575
US Classification:
435/069400, 435/320100, 435/325000, 530/399000, 536/023500
Abstract:
Substantially pure recombinant TSH has been prepared from a clone comprising complete nucleotide sequence for the expression of the TSH. Diagnostic and therapeutic applications of the synthetic TSH are described.
Isolated Modified Human Chorionic Gonadotropin Proteins
US Patent:
2010011, May 6, 2010
Filed:
May 26, 2009
Appl. No.:
12/471983
Inventors:
Bruce D. WEINTRAUB - Rockville MD, US
Mariusz W. Szkudlinski - Potomac MD, US
Mariusz W. Szkudlinski - Potomac MD, US
International Classification:
C07K 14/575
US Classification:
530398
Abstract:
Compositions and methods based on mutant Cystine Knot Growth Factors (CKGFs) comprising amino acid substitutions relative to the wild type hormone/growth factor. Mutated glycoprotein hormones, including thyroid stimulating hormone (TSH) and chorionic gonadotropin (CG) are disclosed as exemplary mutant CKGFs. Mutant TSH heterodimers and hCH heterodimers possessed modified bioactivities, including superagonist activity. Accordingly, the present invention provides methods for using mutant CKGFs, CKGF analogs, fragments, and derivatives thereof for treating or preventing diseases. Pharmaceutical and diagnostic compositions, methods of using mutant TSH heterodimers and TSH analogs with utility for treatment and prevention of metabolic and reproductive diseases are also provided.
Cystine Knot Growth Factor Mutants
US Patent:
2004026, Dec 30, 2004
Filed:
Apr 19, 2004
Appl. No.:
10/826324
Inventors:
Bruce Weintraub - Rockville MD, US
Mariusz Szkudlinski - Potomac MD, US
Mariusz Szkudlinski - Potomac MD, US
International Classification:
A61K038/22, C07K014/575, C07H021/04
US Classification:
435/069400, 435/320100, 435/325000, 530/397000, 514/008000, 536/023500
Abstract:
Compositions and methods based on mutant Cystine Knot Growth Factors (CKGFs) comprising amino acid substitutions relative to the wild type hormone/growth factor. Mutated glycoprotein hormones, including thyroid stimulating hormone (TSH) and chorionic gonadotropin (CG) are disclosed as exemplary mutant CKGFs. Mutant TSH heterodimers and hCH heterodimers possessed modified bioactivities, including superagonist activity. Accordingly, the present invention provides methods for using mutant CKGFs, CKGF analogs, fragments, and derivatives thereof for treating or preventing diseases. Pharmaceutical and diagnostic compositions, methods of using mutant TSH heterodimers and TSH analogs with utility for treatment and prevention of metabolic and reproductive diseases are also provided.
Human Glycoprotein Hormone Superagonists And Uses Thereof
US Patent:
2009021, Aug 27, 2009
Filed:
Mar 18, 2005
Appl. No.:
10/594843
Inventors:
Mariusz W. Szkudlinski - Rockville MD, US
Bruce D. Weintraub - Rockville MD, US
Bruce D. Weintraub - Rockville MD, US
International Classification:
A61K 51/08, A61K 49/00, A61K 49/14, A61K 49/04, A61K 38/14, A61K 39/395, A61K 35/76, A61K 38/21, A61K 38/20, G01N 33/53
US Classification:
424 169, 424 91, 424 96, 424 934, 424 943, 514 8, 4241781, 424 936, 424 857, 424 856, 424 855, 424 852, 436501, 435 71, 435 72
Abstract:
The present invention provides improved methods of imaging, targeted therapy and detection and diagnostics using modified glycoprotein hormones having increased activity over wild-type hormones.
Vegf Analogs And Methods Of Use
US Patent:
2010021, Aug 26, 2010
Filed:
Oct 6, 2006
Appl. No.:
12/089296
Inventors:
Mariusz W. Szkudlinski - Rockville MD, US
Bruce D. Weintraub - Rockville MD, US
Bruce D. Weintraub - Rockville MD, US
International Classification:
A61K 38/18, C07K 14/575, A61P 35/00
US Classification:
514 12, 530399
Abstract:
Modified VEGF proteins that inhibit VEGF-mediated activation or proliferation of endothelial cells are disclosed. The analogs may be used to inhibit VEGF-mediated activation of endothelial cells in angiogenesis-associated diseases such as cancer, inflammatory diseases, eye diseases, and skin disorders.