BRUCE ARTHUR LESSEY
Medical Practice in Hillsborough, NC
License number
Pennsylvania MD041177E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Hillsborough, NC 27278
Pennsylvania
Pennsylvania
Personal information
See more information about BRUCE ARTHUR LESSEY at radaris.comName
Address
Phone
102 Turnberry Ln, Chapel Hill, NC 27517
520 Pleasant Green Rd, Hillsborough, NC 27278
Professional information
.Alpha..sub.v .Beta..sub.3 Integrin As A Predictor Of Endometriosis
US Patent:
5478725, Dec 26, 1995
Filed:
Nov 19, 1993
Appl. No.:
8/155435
Inventors:
Bruce A. Lessey - Hillsborough NC
Assignee:
University of Pennsylvania - Philadelphia PA
International Classification:
G01N 33537, G01N 33543, G01N 33577
US Classification:
435 721
Abstract:
Methods of screening for endometriosis comprise obtaining a sample of endometrium selected from menstrual cycle day 20 to 24, identifying the endometrial sample as nulliparous, contacting the endometrium with a monoclonal antibody for. beta. sub. 3 integrin, assaying for. beta. sub. 3 integrin and correlating the absence of. beta. sub. 3 integrin with endometriosis, wherein the endometrium is identified as mild/minimum endometriosis. A method of using monoclonal antibodies to screen for endometriosis is also within the scope of the invention. Methods for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for. beta. sub. 3 and detecting. beta. sub. 3 in the endometrium.
Determination Of Endometrial Receptivity Toward Embryo Implantation
US Patent:
6960445, Nov 1, 2005
Filed:
Jan 21, 2004
Appl. No.:
10/762441
Inventors:
Bruce Lessey - Hillsborough NC, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
G01N033/53
US Classification:
435 71, 435 721, 436510, 436 65, 436814
Abstract:
Methods of diagnosing infertility in a mammal that include detecting the presence and level of a βintegrin subunit in an endometrium sample of a mammal at a plurality of stages of the endometrial cycle and correlating delayed appearance or a reduced level of βintegrin subunit expression with infertility are provided. Diagnostic kits useful in the practice of the methods of the invention are also provided.
Determination Of Endometrial Receptivity Toward Embryo Implantation
US Patent:
6979533, Dec 27, 2005
Filed:
Jun 16, 2003
Appl. No.:
10/463130
Inventors:
Bruce Lessey - Hillsborough NC, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
G01N033/53
US Classification:
435 4, 435 71
Abstract:
Methods for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for βand detecting βin the endometrium. The invention also provides for methods of diagnosing infertility in a mammal and methods of detecting the window of embryo implantation in endometrium. Methods of in vitro fertilization, methods of preventing embryo implantation and a method of monitoring endometrial maturation are also within the scope of the present invention. The present invention is also directed to contraceptives. Diagnostic kits useful in the practice of the methods of the invention are also provided.