Inventors:
Hitoshi Suzuki - Tokyo, JP
Run Fan - Charlottesville VA, US
Bruce A. Julian - Birmingham AL, US
Jan Novak - Pelham AL, US
Zina Moldoveanu - Birmingham AL, US
Zhixin Zhang - Omaha NE, US
Milan Tomana - Birmingham AL, US
Jiri Mestecky - Birmingham AL, US
Robert J. Wyatt - Memphis TN, US
Yasuhiko Tomino - Tokyo, JP
Yusuke Suzuki - Tokyo, JP
Stephen Olson - Rockville MD, US
International Classification:
A61K 39/395, G01N 33/566, C12Q 1/68, G01N 21/76, C07K 16/00, C07K 16/42, A01K 67/00, A61K 35/16, A61P 13/12, G01N 21/78, C40B 30/04
US Classification:
800 9, 435 792, 435 71, 435 611, 435 612, 506 9, 4241311, 5303872, 424530, 5303871
Abstract:
Provided are methods of diagnosing IgA nephropathy in a subject. Optionally, the methods comprise isolating an IgG from the subject and determining whether the IgG binds to a galactose-deficient IgA1. Optionally, the methods comprise providing a biological sample from the subject and detecting in the sample a mutation in a IGH gene, wherein the mutation is in a nucleotide sequence encoding a complementarity determining region 3 (CDR3) of a IGH variable region. Optionally, the methods comprise determining a level of IgG specific for a galactose-deficient IgA1 in the subject. Also provided are methods of treating or reducing the risk of developing IgA nephropathy in a subject.