Inventors:
Brian L. Henry - Pittsburgh PA, US
Aiye Liang - North Charleston SC, US
Jay Thakkar - Denver CO, US
John B. Mangrum - Richmond VA, US
Ivo Torres Filho - San Antonio TX, US
Bruce D. Spiess - Manakin-Sabot VA, US
Masahiro Sakagami - Richmond VA, US
Bhawana Saluja - North Bethesda MD, US
Assignee:
Virginia Commonwealth University - Richmond VA
International Classification:
A61K 9/12, A61K 31/185, A61K 31/192, A61K 31/343, A61K 31/255, C07C 305/24, C07D 307/80, C07D 307/84, C07D 407/14, A61P 7/02, A61P 29/00, A61P 11/00
US Classification:
424 45, 514469, 514518, 549468, 562 36
Abstract:
Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e. g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e. g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants.