BRIAN L FOX, DO
Marriage and Family Therapists at Ballinger Way, Seattle, WA
License number
Washington 02002911A
Category
Osteopathic Medicine
Type
Family Medicine
Address
Address
20120 Ballinger Way NE, Seattle, WA 98155
Phone
(206) 681-5902
(949) 385-9207 (Fax)
(206) 858-5059
(949) 385-9207 (Fax)
(206) 858-5059
Professional information
Three-Dimensional Structure Of Bovine Rhodopsin
US Patent:
2002014, Oct 3, 2002
Filed:
Aug 3, 2001
Appl. No.:
09/922494
Inventors:
Masashi Miyano - Hyogo, JP
Takashi Kumasaka - Hyogo, JP
Tetsuya Hori - Hyogo, JP
Hiroyuki Motoshima - Hyogo, JP
Tetsuji Okada - Hyogo, JP
Masaki Yamamoto - Hyogo, JP
Krzysztof Palczewski - Seattle WA, US
Craig Behnke - Seattle WA, US
Brian Fox - Seattle WA, US
Isolde Trong - Seattle WA, US
David Teller - Seattle WA, US
Ronald Stenkamp - Seattle WA, US
Takashi Kumasaka - Hyogo, JP
Tetsuya Hori - Hyogo, JP
Hiroyuki Motoshima - Hyogo, JP
Tetsuji Okada - Hyogo, JP
Masaki Yamamoto - Hyogo, JP
Krzysztof Palczewski - Seattle WA, US
Craig Behnke - Seattle WA, US
Brian Fox - Seattle WA, US
Isolde Trong - Seattle WA, US
David Teller - Seattle WA, US
Ronald Stenkamp - Seattle WA, US
International Classification:
C07K014/705, C07H021/04, C12P021/02, C12N005/06
US Classification:
435/069100, 435/320100, 435/325000, 530/350000, 536/023500
Abstract:
The present invention discloses a three-dimensional structure of bovine rhodopsin. There is provided a G protein-coupled receptor selected from the group consisting of the following (a) and (b): (a) a G protein-coupled receptor having three-dimensional structure I defined by the atomic coordinates as shown in Table 1; (b) a G protein-coupled receptor having three-dimensional structure II defined by derived coordinates from the atomic coordinates as shown in Table 1, wherein the mean residual of the discrepancies between the positions of the carbon atoms in the amino acid residues of seven helix sites H-I (36-64), H-II (71-100), H-III (107-139), H-IV (151-173), H-V (200-225), H-VI (247-277) and H-VII (286-306) in the amino acid sequence as shown in SEQ ID NO: 1 of the three-dimensional structure I and the positions of the corresponding carbon atoms in the amino acid residues of the corresponding seven helix sites of the three-dimensional structure II is 1.5 or less when an image of the three-dimensional structure I obtained by computer-processing the atomic coordinates of Table 1 and an image of the three-dimensional structure II obtained by computer-processing the derived coordinates are superposed.
Nucleic Acid Encoding A Human Allelic Variant Of Interferon-Like Protein Zcyto21
US Patent:
7445913, Nov 4, 2008
Filed:
Oct 10, 2006
Appl. No.:
11/548023
Inventors:
Paul O. Sheppard - Granite Falls WA, US
Scott R. Presnell - Tacoma WA, US
Brian A. Fox - Seattle WA, US
Teresa Gilbert - Seattle WA, US
Betty A. Haldeman - Seattle WA, US
Francis J. Grant - Seattle WA, US
Scott R. Presnell - Tacoma WA, US
Brian A. Fox - Seattle WA, US
Teresa Gilbert - Seattle WA, US
Betty A. Haldeman - Seattle WA, US
Francis J. Grant - Seattle WA, US
Assignee:
ZymoGenetics, Inc. - Seattle WA
International Classification:
C12P 21/06, C07H 21/04, C12P 21/02, C12P 21/04, C12N 5/00, A61K 38/21, C07K 1/00
US Classification:
435 691, 435 695, 435 6951, 435 701, 435325, 424 854, 530351, 536 235
Abstract:
The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
Kunitz Domain Polypeptide Zkun10
US Patent:
6914135, Jul 5, 2005
Filed:
Dec 9, 2002
Appl. No.:
10/315432
Inventors:
Paul O. Sheppard - Granite Falls WA, US
Brian A. Fox - Seattle WA, US
Brian A. Fox - Seattle WA, US
Assignee:
ZymoGenetics, Inc. - Seattle WA
International Classification:
C07H021/02, C12Q001/34
US Classification:
536 231, 435 691, 4353201, 4352523, 435325, 435 18
Abstract:
Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a motif of amino acid residues as shown in SEQ ID NO:4, and the sequence of the Kunitz domain is shown in residues 57 through 107 of SEQ ID NO:2. The polypeptide also includes an N-terminal collagen domain in which a von Willebrand domain resides, and is shown in SEQ ID NO: 5. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and as inhibitors of protease degradation of plasma proteins.
Nucleic Acid Encoding A Human Interferon-Like Protein Zcyto21
US Patent:
7498154, Mar 3, 2009
Filed:
Oct 26, 2007
Appl. No.:
11/925097
Inventors:
Paul O. Sheppard - Granite Falls WA, US
Scott R. Presnell - Tacoma WA, US
Brian A. Fox - Seattle WA, US
Teresa Gilbert - Seattle WA, US
Betty A. Haldeman - Seattle WA, US
Francis J. Grant - Seattle WA, US
Scott R. Presnell - Tacoma WA, US
Brian A. Fox - Seattle WA, US
Teresa Gilbert - Seattle WA, US
Betty A. Haldeman - Seattle WA, US
Francis J. Grant - Seattle WA, US
Assignee:
ZymoGenetics, Inc. - Seattle WA
International Classification:
C12P 21/06, C07H 21/04, C12P 21/02, C12P 21/04, C12N 5/00, A61K 38/21, C07K 1/00
US Classification:
435 691, 435 695, 435 6951, 435 701, 435325, 424 854, 530351, 536 235
Abstract:
The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
Method Of Using Interferon-Like Protein Zcyto21 (Il-29) To Treat Hepatitis C
US Patent:
7655223, Feb 2, 2010
Filed:
Oct 16, 2007
Appl. No.:
11/873272
Inventors:
Paul O. Sheppard - Granite Falls WA, US
Scott R. Presnell - Tacoma WA, US
Brian A. Fox - Seattle WA, US
Teresa Gilbert - Seattle WA, US
Betty A. Haldeman - Seattle WA, US
Francis J. Grant - Seattle WA, US
Scott R. Presnell - Tacoma WA, US
Brian A. Fox - Seattle WA, US
Teresa Gilbert - Seattle WA, US
Betty A. Haldeman - Seattle WA, US
Francis J. Grant - Seattle WA, US
Assignee:
ZymoGenetics, LLC - Nashville TN
International Classification:
A61K 38/20, A61K 38/21, A61K 38/00, C07K 14/00
US Classification:
424 852, 424 854, 514 12, 530351, 530402
Abstract:
The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
Peptide And Polypeptide Inhibitors Of Complement C1S
US Patent:
2005026, Dec 1, 2005
Filed:
Jun 20, 2005
Appl. No.:
11/156843
Inventors:
Robert West - Seattle WA, US
Paul Sheppard - Granite Falls WA, US
Brian Fox - Seattle WA, US
Paul Sheppard - Granite Falls WA, US
Brian Fox - Seattle WA, US
International Classification:
A61K038/10, A61K038/08, C07K007/08, C07K007/06
US Classification:
514013000, 514014000, 514015000, 530326000, 530327000, 530328000, 530329000
Abstract:
The complement system plays an important role in providing resistance to infections and in the pathogenesis of tissue injury. Yet an inappropriate activation of complement can result in a variety of disorders. The present invention provides C1s catalytic site-directed moieties, C1s exosite binding moieties, and bivalent polypeptide inhibitors comprising such moieties, which can be used to treat conditions characterized by inappropriate complement activation.
Ztnf11, A Tumor Necrosis Factor
US Patent:
2005025, Nov 17, 2005
Filed:
Nov 22, 2004
Appl. No.:
10/994820
Inventors:
Zeren Gao - Redmond WA, US
Paul Sheppard - Granite Falls WA, US
Brian Fox - Seattle WA, US
James Holloway - Seattle WA, US
Stephen Jaspers - Edmonds WA, US
Paul Sheppard - Granite Falls WA, US
Brian Fox - Seattle WA, US
James Holloway - Seattle WA, US
Stephen Jaspers - Edmonds WA, US
International Classification:
C07H021/04, C12P021/02, C07K014/525, C07K016/24
US Classification:
435069500, 435320100, 435325000, 530351000, 530388230, 536023500
Abstract:
Novel tumor necrosis factor ligand polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides may be used within methods relating to immune response, and may also be used in the development of immuno-regulatory therapeutics. Also provided are antibodies, binding proteins, agonists and antagonists of the ligand polypeptides.
Adipocyte Complement Related Protein Zacrp11
US Patent:
2002016, Oct 31, 2002
Filed:
Nov 16, 2001
Appl. No.:
09/998582
Inventors:
Brian Fox - Seattle WA, US
International Classification:
C12N009/00, C07H021/04, C12P021/04, C12P021/02, C12N005/06, C07K014/78
US Classification:
435/183000, 530/356000, 435/069700, 435/325000, 435/320100, 536/023200
Abstract:
The present invention relates to polynucleotide and polypeptide molecules for zacrp11, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. Novel zacrp11 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp11 protein or fragments thereof.
Cub Domain Protein Zcub3 And Materials And Methods For Making It
US Patent:
2003002, Jan 30, 2003
Filed:
Jan 23, 2002
Appl. No.:
10/055228
Inventors:
Brian Fox - Seattle WA, US
David Taft - Seattle WA, US
Paul Sheppard - Granite Falls WA, US
David Taft - Seattle WA, US
Paul Sheppard - Granite Falls WA, US
International Classification:
C12P021/02, C07K014/435, C07H021/04, C12N005/06
US Classification:
435/069700, 435/320100, 435/325000, 530/350000, 536/023500
Abstract:
Novel polypeptides, materials and methods for making them, and method of use are disclosed. The polypeptides comprise at least fifteen contiguous amino acid residues of SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, or SEQ ID NO:9 and may be prepared as polypeptide fusions comprise heterologous sequences, such as affinity tags. The polypeptides and polynucleotides encoding them may be used within a variety of therepeutic, diagnostic, and research applications.
Interferon-Like Protein Zcyto21
US Patent:
2007004, Mar 1, 2007
Filed:
Oct 10, 2006
Appl. No.:
11/548138
Inventors:
Paul Sheppard - Granile Falls WA, US
Scott Presnell - Tacoma WA, US
Brian Fox - Seattle WA, US
Teresa Gilbert - Seattle WA, US
Betty Haldeman - Seattle WA, US
Francis Grant - Seattle WA, US
Scott Presnell - Tacoma WA, US
Brian Fox - Seattle WA, US
Teresa Gilbert - Seattle WA, US
Betty Haldeman - Seattle WA, US
Francis Grant - Seattle WA, US
International Classification:
C07K 16/24
US Classification:
530388230
Abstract:
The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.